miRNAs as cornerstones in diabetic microvascular complications

Diabetes mellitus is usually accompanied by nephropathy, retinopathy, and neuropathy as microvascular complications. MicroRNAs (miRNAs) can affect the kidney, retina, and peripheral neurons through their implication in pathways involved in angiogenesis, inflammation, apoptosis, as well as fibrosis w...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2023-01, Vol.138 (1), p.106978-106978, Article 106978
Main Authors: Ismail, Ahmed, El-Mahdy, Hesham A., Eldeib, Mahmoud Gomaa, Doghish, Ahmed S.
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 2 - complications
Diabetic nephropathy
Diabetic neuropathy
Diabetic retinopathy
Diabetic Retinopathy - complications
Diabetic Retinopathy - genetics
Diabetic Retinopathy - pathology
Humans
Inflammation - complications
Inflammation - genetics
Kidney
MicroRNAs - genetics
Microvascular complications
Retina - pathology
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Summary:Diabetes mellitus is usually accompanied by nephropathy, retinopathy, and neuropathy as microvascular complications. MicroRNAs (miRNAs) can affect the kidney, retina, and peripheral neurons through their implication in pathways involved in angiogenesis, inflammation, apoptosis, as well as fibrosis within these tissues and hence, play a crucial role in the pathogenesis of microvascular complications. In this review, the updated knowledge of the role of miRNAs in the pathogenesis of diabetic microvascular complications was summarized. PubMed Central was searched extensively to retrieve data from a wide range of reputable biomedical reports/articles published after the year 2000 to systematically collect and present a review of the key molecular pathways mediating the hyperglycemia-induced adverse effects on vascular tissues, particularly in persons with T2DM. In the present review, miR-126, miR-29b, and miR-125a are implicated in diabetes-induced microvascular complications, while miR-146a is found to be connected to all these complications. Also, vascular endothelial growth factors are noted to be the most impacted targets by miRNAs in all diabetic microvascular problems. [Display omitted] •We update miRNAs' role in diabetic microvascular complications.•miRNAs serve a critical role in regulation of many biological processes in diabetes.•miRNAs have appeared as novel diabetic biomarkers and a possible therapeutic target.
ISSN:1096-7192
1096-7206
DOI:10.1016/j.ymgme.2022.106978