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High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study
Objective Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lip...
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| Published in: | Clinical endocrinology (Oxford) 2023-03, Vol.98 (3), p.375-382 |
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| container_end_page | 382 |
| container_issue | 3 |
| container_start_page | 375 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 98 |
| creator | Laway, Bashir Ahmad Rasool, Abid Baba, Mohammad Salem Misgar, Raiz Ahmad Bashir, Mir Iftikhar Wani, Arshad Iqbal Choh, Naseer Shah, Omair Lone, Ajaz Shah, Zaffar |
| description | Objective
Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10‐year probability of cardiovascular (CV) events in SS patients.
Design
Case–control study Sixty‐three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity‐matched controls.
Measurements
Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16‐row multislice computed tomography scanner.
Results
The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p 10) for incident CV events as against 1.6% controls. The mean Multi‐Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r = .316), ApoB (r = .549), LP(a) (r = .310) and FRS (r = .294).
Conclusion
Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD. |
| doi_str_mv | 10.1111/cen.14871 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2758353986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2758353986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-e5867280330d33f2ef3220eda395a38016134bc4648d546d940c3380aef62b233</originalsourceid><addsrcrecordid>eNp10cFuEzEQBmALgUgaOPACyBIXOGw6tne9m2MVFYIUwQE4rxx7ljhs7GDvUuXGO7SnPh5PwpQUDiB8Gcv6_I_lYeyZgLmgdW4xzEXZ1OIBmwqlq0JKXT1kU1AABWhdTthZzjsAqBqoH7MJGV2XQkzZ7cp_3vJDwm-mx2CRx47bmGIw6chNGpCKNb31nbdm8DFwExz3wSY0GR1PPn_hXUz_XHI-3wmi_EAXMQyZX_lhyz9sEbcm8HwMLsU9_vh-c0EtMm2ubQxDij3Pw-iOT9ijzvQZn97XGfv0-vLjclWs3795u7xYF1ZVShRYNbqWDSgFTqlOYqekBHRGLSqjGhBaqHJjS102riq1W5RgFZ0b7LTcSKVm7OUp95Di1xHz0O59ttj3JmAccyvrqqFOi0YTffEX3cUxBXodqboGkLUUpF6dlE0x54Rde0h-T3_TCmjvBtbSwNpfAyP7_D5x3OzR_ZG_J0Tg_ASufI_H_ye1y8t3p8if-6eimg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2777002721</pqid></control><display><type>article</type><title>High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study</title><source>Wiley</source><creator>Laway, Bashir Ahmad ; Rasool, Abid ; Baba, Mohammad Salem ; Misgar, Raiz Ahmad ; Bashir, Mir Iftikhar ; Wani, Arshad Iqbal ; Choh, Naseer ; Shah, Omair ; Lone, Ajaz ; Shah, Zaffar</creator><creatorcontrib>Laway, Bashir Ahmad ; Rasool, Abid ; Baba, Mohammad Salem ; Misgar, Raiz Ahmad ; Bashir, Mir Iftikhar ; Wani, Arshad Iqbal ; Choh, Naseer ; Shah, Omair ; Lone, Ajaz ; Shah, Zaffar</creatorcontrib><description>Objective
Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10‐year probability of cardiovascular (CV) events in SS patients.
Design
Case–control study Sixty‐three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity‐matched controls.
Measurements
Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16‐row multislice computed tomography scanner.
Results
The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p < .01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (p = .006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC > 10) for incident CV events as against 1.6% controls. The mean Multi‐Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r = .316), ApoB (r = .549), LP(a) (r = .310) and FRS (r = .294).
Conclusion
Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14871</identifier><identifier>PMID: 36567411</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>agatston score ; Apolipoprotein B ; Arteriosclerosis ; Body mass index ; C-reactive protein ; C-Reactive Protein - metabolism ; Calcification (ectopic) ; Calcium ; Cardiovascular disease ; Case-Control Studies ; Computed tomography ; coronary artery calcium ; Coronary artery disease ; Coronary Artery Disease - etiology ; Coronary Artery Disease - metabolism ; Coronary Vessels ; Dyslipidemia ; Framingham score ; Growth hormones ; Heart diseases ; Humans ; Hypopituitarism - complications ; panhypopituitarism ; Prevalence ; Risk Factors ; Sheehan syndrome ; Vascular Calcification - etiology ; Vascular Calcification - metabolism ; Vein & artery diseases</subject><ispartof>Clinical endocrinology (Oxford), 2023-03, Vol.98 (3), p.375-382</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-e5867280330d33f2ef3220eda395a38016134bc4648d546d940c3380aef62b233</citedby><cites>FETCH-LOGICAL-c3531-e5867280330d33f2ef3220eda395a38016134bc4648d546d940c3380aef62b233</cites><orcidid>0000-0002-5437-2518 ; 0000-0003-1553-9407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36567411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laway, Bashir Ahmad</creatorcontrib><creatorcontrib>Rasool, Abid</creatorcontrib><creatorcontrib>Baba, Mohammad Salem</creatorcontrib><creatorcontrib>Misgar, Raiz Ahmad</creatorcontrib><creatorcontrib>Bashir, Mir Iftikhar</creatorcontrib><creatorcontrib>Wani, Arshad Iqbal</creatorcontrib><creatorcontrib>Choh, Naseer</creatorcontrib><creatorcontrib>Shah, Omair</creatorcontrib><creatorcontrib>Lone, Ajaz</creatorcontrib><creatorcontrib>Shah, Zaffar</creatorcontrib><title>High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Objective
Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10‐year probability of cardiovascular (CV) events in SS patients.
Design
Case–control study Sixty‐three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity‐matched controls.
Measurements
Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16‐row multislice computed tomography scanner.
Results
The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p < .01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (p = .006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC > 10) for incident CV events as against 1.6% controls. The mean Multi‐Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r = .316), ApoB (r = .549), LP(a) (r = .310) and FRS (r = .294).
Conclusion
Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.</description><subject>agatston score</subject><subject>Apolipoprotein B</subject><subject>Arteriosclerosis</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcification (ectopic)</subject><subject>Calcium</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Computed tomography</subject><subject>coronary artery calcium</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Vessels</subject><subject>Dyslipidemia</subject><subject>Framingham score</subject><subject>Growth hormones</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypopituitarism - complications</subject><subject>panhypopituitarism</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sheehan syndrome</subject><subject>Vascular Calcification - etiology</subject><subject>Vascular Calcification - metabolism</subject><subject>Vein & artery diseases</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10cFuEzEQBmALgUgaOPACyBIXOGw6tne9m2MVFYIUwQE4rxx7ljhs7GDvUuXGO7SnPh5PwpQUDiB8Gcv6_I_lYeyZgLmgdW4xzEXZ1OIBmwqlq0JKXT1kU1AABWhdTthZzjsAqBqoH7MJGV2XQkzZ7cp_3vJDwm-mx2CRx47bmGIw6chNGpCKNb31nbdm8DFwExz3wSY0GR1PPn_hXUz_XHI-3wmi_EAXMQyZX_lhyz9sEbcm8HwMLsU9_vh-c0EtMm2ubQxDij3Pw-iOT9ijzvQZn97XGfv0-vLjclWs3795u7xYF1ZVShRYNbqWDSgFTqlOYqekBHRGLSqjGhBaqHJjS102riq1W5RgFZ0b7LTcSKVm7OUp95Di1xHz0O59ttj3JmAccyvrqqFOi0YTffEX3cUxBXodqboGkLUUpF6dlE0x54Rde0h-T3_TCmjvBtbSwNpfAyP7_D5x3OzR_ZG_J0Tg_ASufI_H_ye1y8t3p8if-6eimg</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Laway, Bashir Ahmad</creator><creator>Rasool, Abid</creator><creator>Baba, Mohammad Salem</creator><creator>Misgar, Raiz Ahmad</creator><creator>Bashir, Mir Iftikhar</creator><creator>Wani, Arshad Iqbal</creator><creator>Choh, Naseer</creator><creator>Shah, Omair</creator><creator>Lone, Ajaz</creator><creator>Shah, Zaffar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5437-2518</orcidid><orcidid>https://orcid.org/0000-0003-1553-9407</orcidid></search><sort><creationdate>202303</creationdate><title>High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study</title><author>Laway, Bashir Ahmad ; Rasool, Abid ; Baba, Mohammad Salem ; Misgar, Raiz Ahmad ; Bashir, Mir Iftikhar ; Wani, Arshad Iqbal ; Choh, Naseer ; Shah, Omair ; Lone, Ajaz ; Shah, Zaffar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-e5867280330d33f2ef3220eda395a38016134bc4648d546d940c3380aef62b233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>agatston score</topic><topic>Apolipoprotein B</topic><topic>Arteriosclerosis</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Calcification (ectopic)</topic><topic>Calcium</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Computed tomography</topic><topic>coronary artery calcium</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary Vessels</topic><topic>Dyslipidemia</topic><topic>Framingham score</topic><topic>Growth hormones</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypopituitarism - complications</topic><topic>panhypopituitarism</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sheehan syndrome</topic><topic>Vascular Calcification - etiology</topic><topic>Vascular Calcification - metabolism</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laway, Bashir Ahmad</creatorcontrib><creatorcontrib>Rasool, Abid</creatorcontrib><creatorcontrib>Baba, Mohammad Salem</creatorcontrib><creatorcontrib>Misgar, Raiz Ahmad</creatorcontrib><creatorcontrib>Bashir, Mir Iftikhar</creatorcontrib><creatorcontrib>Wani, Arshad Iqbal</creatorcontrib><creatorcontrib>Choh, Naseer</creatorcontrib><creatorcontrib>Shah, Omair</creatorcontrib><creatorcontrib>Lone, Ajaz</creatorcontrib><creatorcontrib>Shah, Zaffar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laway, Bashir Ahmad</au><au>Rasool, Abid</au><au>Baba, Mohammad Salem</au><au>Misgar, Raiz Ahmad</au><au>Bashir, Mir Iftikhar</au><au>Wani, Arshad Iqbal</au><au>Choh, Naseer</au><au>Shah, Omair</au><au>Lone, Ajaz</au><au>Shah, Zaffar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2023-03</date><risdate>2023</risdate><volume>98</volume><issue>3</issue><spage>375</spage><epage>382</epage><pages>375-382</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Objective
Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10‐year probability of cardiovascular (CV) events in SS patients.
Design
Case–control study Sixty‐three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity‐matched controls.
Measurements
Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16‐row multislice computed tomography scanner.
Results
The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p < .01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (p = .006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC > 10) for incident CV events as against 1.6% controls. The mean Multi‐Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r = .316), ApoB (r = .549), LP(a) (r = .310) and FRS (r = .294).
Conclusion
Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36567411</pmid><doi>10.1111/cen.14871</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5437-2518</orcidid><orcidid>https://orcid.org/0000-0003-1553-9407</orcidid></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2023-03, Vol.98 (3), p.375-382 |
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| language | eng |
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| source | Wiley |
| subjects | agatston score Apolipoprotein B Arteriosclerosis Body mass index C-reactive protein C-Reactive Protein - metabolism Calcification (ectopic) Calcium Cardiovascular disease Case-Control Studies Computed tomography coronary artery calcium Coronary artery disease Coronary Artery Disease - etiology Coronary Artery Disease - metabolism Coronary Vessels Dyslipidemia Framingham score Growth hormones Heart diseases Humans Hypopituitarism - complications panhypopituitarism Prevalence Risk Factors Sheehan syndrome Vascular Calcification - etiology Vascular Calcification - metabolism Vein & artery diseases |
| title | High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study |
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