The use of Vaccinia Immune Globulin in the Treatment of Severe Mpox. Virus Infection in Human Immunodeficiency Virus/AIDS

Abstract We report a case of progressive, severe mpox virus (MPXV) infection in a patient with AIDS despite a standard course of tecovirimat. He significantly improved after administration of vaccinia immune globulin intravenous (VIGIV) highlighting its use as an adjunct for severe disease in immuno...

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Bibliographic Details
Published in:Clinical infectious diseases 2023-05, Vol.76 (9), p.1671-1673
Main Authors: Thet, Andrea K, Kelly, Paul J, Kasule, Sabirah N, Shah, Anish K, Chawala, Arpan, Latif, Amber, Chilimuri, Sridhar S, Zeana, Cosmina B
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome
HIV
Humans
Immunoglobulins
Immunologic Factors
Male
Mpox (monkeypox)
Vaccinia - therapy
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Summary:Abstract We report a case of progressive, severe mpox virus (MPXV) infection in a patient with AIDS despite a standard course of tecovirimat. He significantly improved after administration of vaccinia immune globulin intravenous (VIGIV) highlighting its use as an adjunct for severe disease in immunocompromised hosts.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac971