The use of Vaccinia Immune Globulin in the Treatment of Severe Mpox. Virus Infection in Human Immunodeficiency Virus/AIDS

Abstract We report a case of progressive, severe mpox virus (MPXV) infection in a patient with AIDS despite a standard course of tecovirimat. He significantly improved after administration of vaccinia immune globulin intravenous (VIGIV) highlighting its use as an adjunct for severe disease in immuno...

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Published in:Clinical infectious diseases 2023-05, Vol.76 (9), p.1671-1673
Main Authors: Thet, Andrea K, Kelly, Paul J, Kasule, Sabirah N, Shah, Anish K, Chawala, Arpan, Latif, Amber, Chilimuri, Sridhar S, Zeana, Cosmina B
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome
HIV
Humans
Immunoglobulins
Immunologic Factors
Male
Mpox (monkeypox)
Vaccinia - therapy
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container_end_page 1673
container_issue 9
container_start_page 1671
container_title Clinical infectious diseases
container_volume 76
creator Thet, Andrea K
Kelly, Paul J
Kasule, Sabirah N
Shah, Anish K
Chawala, Arpan
Latif, Amber
Chilimuri, Sridhar S
Zeana, Cosmina B
description Abstract We report a case of progressive, severe mpox virus (MPXV) infection in a patient with AIDS despite a standard course of tecovirimat. He significantly improved after administration of vaccinia immune globulin intravenous (VIGIV) highlighting its use as an adjunct for severe disease in immunocompromised hosts.
doi_str_mv 10.1093/cid/ciac971
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source Oxford Journals Online
subjects Acquired Immunodeficiency Syndrome
HIV
Humans
Immunoglobulins
Immunologic Factors
Male
Mpox (monkeypox)
Vaccinia - therapy
title The use of Vaccinia Immune Globulin in the Treatment of Severe Mpox. Virus Infection in Human Immunodeficiency Virus/AIDS
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