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Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls
Recent evidence indicates that DDR1 participates in myelination and that variants of DDR1 are associated with decreased cognitive processing speed (PS) in schizophrenia (SZ). Here, we explored whether DDR1 variants were associated with PS in subjects diagnosed with an early psychosis (EP), a conditi...
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Published in: | Journal of psychiatric research 2023-02, Vol.158, p.49-55 |
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creator | Gas, Cinta Ayesa-Arriola, Rosa Vázquez-Bourgon, Javier Crespo-Facorro, Benedicto García-Gavilán, Jesús Labad, Javier Martorell, Lourdes Muntané, Gerard Sanchez-Gistau, Vanessa Vilella, Elisabet |
description | Recent evidence indicates that DDR1 participates in myelination and that variants of DDR1 are associated with decreased cognitive processing speed (PS) in schizophrenia (SZ). Here, we explored whether DDR1 variants were associated with PS in subjects diagnosed with an early psychosis (EP), a condition often preceding SZ. Data from two Spanish independent samples (from Reus and Santander) including patients with EP (n = 75 and n = 312, respectively) and healthy controls (HCs; n = 57 and n = 160) were analyzed. The Trail Making Test part A was used to evaluate PS. Participants underwent genotyping to identify DDR1 variants rs1264323 and rs2267641. Cross-sectional data were analyzed with general linear models and longitudinal data were analyzed using mixed models. We examined the combined rs1264323AA-rs2267641AC/CC genotypes (an SZ-risk combination) on PS. The SZ-risk combined genotypes were associated with increased PS in EP patients but not in HCs in the cross-sectional analysis. In the longitudinal analysis, the SZ-risk combined genotypes were significantly associated with increased PS in both HCs and EP patients throughout the 10-year follow-up but no genotype × time interaction was observed. These results provide further evidence that DDR1 is involved in cognition and should be replicated with other samples.
•Patients with an early psychosis carrying DDR1 schizophrenia-risk genotype had faster processing speed than the non-carriers.•Healthy controls carrying DDR1 schizophrenia-risk genotype compared to non-carriers did not show faster processing speed.•Participants carrying DDR1 schizophrenia-risk genotype had faster processing speed over a 10-year follow-up period. |
doi_str_mv | 10.1016/j.jpsychires.2022.12.020 |
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•Patients with an early psychosis carrying DDR1 schizophrenia-risk genotype had faster processing speed than the non-carriers.•Healthy controls carrying DDR1 schizophrenia-risk genotype compared to non-carriers did not show faster processing speed.•Participants carrying DDR1 schizophrenia-risk genotype had faster processing speed over a 10-year follow-up period.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2022.12.020</identifier><identifier>PMID: 36571911</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cognition ; Cross-Sectional Studies ; DDR1 ; Discoidin Domain Receptor 1 - genetics ; Early-phase psychosis ; Humans ; Processing Speed ; Psychotic Disorders - genetics ; Schizophrenia - diagnosis ; Schizophrenia - genetics</subject><ispartof>Journal of psychiatric research, 2023-02, Vol.158, p.49-55</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-2a9b685bdc1ad2cccc05fb25704b2578a9f92ec3f3195f53fdda1ec50a4855083</citedby><cites>FETCH-LOGICAL-c374t-2a9b685bdc1ad2cccc05fb25704b2578a9f92ec3f3195f53fdda1ec50a4855083</cites><orcidid>0000-0003-2214-1886 ; 0000-0002-3707-5255 ; 0000-0002-5478-3376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36571911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gas, Cinta</creatorcontrib><creatorcontrib>Ayesa-Arriola, Rosa</creatorcontrib><creatorcontrib>Vázquez-Bourgon, Javier</creatorcontrib><creatorcontrib>Crespo-Facorro, Benedicto</creatorcontrib><creatorcontrib>García-Gavilán, Jesús</creatorcontrib><creatorcontrib>Labad, Javier</creatorcontrib><creatorcontrib>Martorell, Lourdes</creatorcontrib><creatorcontrib>Muntané, Gerard</creatorcontrib><creatorcontrib>Sanchez-Gistau, Vanessa</creatorcontrib><creatorcontrib>Vilella, Elisabet</creatorcontrib><title>Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Recent evidence indicates that DDR1 participates in myelination and that variants of DDR1 are associated with decreased cognitive processing speed (PS) in schizophrenia (SZ). Here, we explored whether DDR1 variants were associated with PS in subjects diagnosed with an early psychosis (EP), a condition often preceding SZ. Data from two Spanish independent samples (from Reus and Santander) including patients with EP (n = 75 and n = 312, respectively) and healthy controls (HCs; n = 57 and n = 160) were analyzed. The Trail Making Test part A was used to evaluate PS. Participants underwent genotyping to identify DDR1 variants rs1264323 and rs2267641. Cross-sectional data were analyzed with general linear models and longitudinal data were analyzed using mixed models. We examined the combined rs1264323AA-rs2267641AC/CC genotypes (an SZ-risk combination) on PS. The SZ-risk combined genotypes were associated with increased PS in EP patients but not in HCs in the cross-sectional analysis. In the longitudinal analysis, the SZ-risk combined genotypes were significantly associated with increased PS in both HCs and EP patients throughout the 10-year follow-up but no genotype × time interaction was observed. These results provide further evidence that DDR1 is involved in cognition and should be replicated with other samples.
•Patients with an early psychosis carrying DDR1 schizophrenia-risk genotype had faster processing speed than the non-carriers.•Healthy controls carrying DDR1 schizophrenia-risk genotype compared to non-carriers did not show faster processing speed.•Participants carrying DDR1 schizophrenia-risk genotype had faster processing speed over a 10-year follow-up period.</description><subject>Cognition</subject><subject>Cross-Sectional Studies</subject><subject>DDR1</subject><subject>Discoidin Domain Receptor 1 - genetics</subject><subject>Early-phase psychosis</subject><subject>Humans</subject><subject>Processing Speed</subject><subject>Psychotic Disorders - genetics</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkV2P1CAUhonRuOPqXzBcetMKdCjtpc76lWxiYvSaUDjdMulA5TC7mV_jX5XOrHopF5Ac3ud8vYRQzmrOePt2X-8XPNnJJ8BaMCFqLmom2BOy4Z3qK96o_inZsPJTNb1sr8gLxD1jTAm-fU6umlYq3nO-Ib92KSJWCDb7GMxMTXB0juHO56Pz5wAiIB4gZBpHmidYI9F6swJ0gPwAEOjNzTdO703yJmQ8J1lStAX04Y7iAuCoD3QpEKyCB58nCibNJ3oeJKK_UBOYOU8namPIKc74kjwbzYzw6vG9Jj8-fvi--1zdfv30ZffutrKN2uZKmH5oOzk4y40Tthwmx0FIxbbr3Zl-7AXYZmx4L0fZjM4ZDlYys-2kZF1zTd5c8pa2fx4Bsz54tDDPJkA8ohZKdlIp3vIi7S5Su64uwaiX5A8mnTRnerVH7_U_e_Rqj-ZCF3sK-vqxynE4gPsL_vGjCN5fBFBmvfeQNNqyMQuu5LJZu-j_X-U3xQirfA</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Gas, Cinta</creator><creator>Ayesa-Arriola, Rosa</creator><creator>Vázquez-Bourgon, Javier</creator><creator>Crespo-Facorro, Benedicto</creator><creator>García-Gavilán, Jesús</creator><creator>Labad, Javier</creator><creator>Martorell, Lourdes</creator><creator>Muntané, Gerard</creator><creator>Sanchez-Gistau, Vanessa</creator><creator>Vilella, Elisabet</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2214-1886</orcidid><orcidid>https://orcid.org/0000-0002-3707-5255</orcidid><orcidid>https://orcid.org/0000-0002-5478-3376</orcidid></search><sort><creationdate>202302</creationdate><title>Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls</title><author>Gas, Cinta ; Ayesa-Arriola, Rosa ; Vázquez-Bourgon, Javier ; Crespo-Facorro, Benedicto ; García-Gavilán, Jesús ; Labad, Javier ; Martorell, Lourdes ; Muntané, Gerard ; Sanchez-Gistau, Vanessa ; Vilella, Elisabet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-2a9b685bdc1ad2cccc05fb25704b2578a9f92ec3f3195f53fdda1ec50a4855083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cognition</topic><topic>Cross-Sectional Studies</topic><topic>DDR1</topic><topic>Discoidin Domain Receptor 1 - genetics</topic><topic>Early-phase psychosis</topic><topic>Humans</topic><topic>Processing Speed</topic><topic>Psychotic Disorders - genetics</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gas, Cinta</creatorcontrib><creatorcontrib>Ayesa-Arriola, Rosa</creatorcontrib><creatorcontrib>Vázquez-Bourgon, Javier</creatorcontrib><creatorcontrib>Crespo-Facorro, Benedicto</creatorcontrib><creatorcontrib>García-Gavilán, Jesús</creatorcontrib><creatorcontrib>Labad, Javier</creatorcontrib><creatorcontrib>Martorell, Lourdes</creatorcontrib><creatorcontrib>Muntané, Gerard</creatorcontrib><creatorcontrib>Sanchez-Gistau, Vanessa</creatorcontrib><creatorcontrib>Vilella, Elisabet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gas, Cinta</au><au>Ayesa-Arriola, Rosa</au><au>Vázquez-Bourgon, Javier</au><au>Crespo-Facorro, Benedicto</au><au>García-Gavilán, Jesús</au><au>Labad, Javier</au><au>Martorell, Lourdes</au><au>Muntané, Gerard</au><au>Sanchez-Gistau, Vanessa</au><au>Vilella, Elisabet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2023-02</date><risdate>2023</risdate><volume>158</volume><spage>49</spage><epage>55</epage><pages>49-55</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Recent evidence indicates that DDR1 participates in myelination and that variants of DDR1 are associated with decreased cognitive processing speed (PS) in schizophrenia (SZ). Here, we explored whether DDR1 variants were associated with PS in subjects diagnosed with an early psychosis (EP), a condition often preceding SZ. Data from two Spanish independent samples (from Reus and Santander) including patients with EP (n = 75 and n = 312, respectively) and healthy controls (HCs; n = 57 and n = 160) were analyzed. The Trail Making Test part A was used to evaluate PS. Participants underwent genotyping to identify DDR1 variants rs1264323 and rs2267641. Cross-sectional data were analyzed with general linear models and longitudinal data were analyzed using mixed models. We examined the combined rs1264323AA-rs2267641AC/CC genotypes (an SZ-risk combination) on PS. The SZ-risk combined genotypes were associated with increased PS in EP patients but not in HCs in the cross-sectional analysis. In the longitudinal analysis, the SZ-risk combined genotypes were significantly associated with increased PS in both HCs and EP patients throughout the 10-year follow-up but no genotype × time interaction was observed. These results provide further evidence that DDR1 is involved in cognition and should be replicated with other samples.
•Patients with an early psychosis carrying DDR1 schizophrenia-risk genotype had faster processing speed than the non-carriers.•Healthy controls carrying DDR1 schizophrenia-risk genotype compared to non-carriers did not show faster processing speed.•Participants carrying DDR1 schizophrenia-risk genotype had faster processing speed over a 10-year follow-up period.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36571911</pmid><doi>10.1016/j.jpsychires.2022.12.020</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2214-1886</orcidid><orcidid>https://orcid.org/0000-0002-3707-5255</orcidid><orcidid>https://orcid.org/0000-0002-5478-3376</orcidid></addata></record> |
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subjects | Cognition Cross-Sectional Studies DDR1 Discoidin Domain Receptor 1 - genetics Early-phase psychosis Humans Processing Speed Psychotic Disorders - genetics Schizophrenia - diagnosis Schizophrenia - genetics |
title | Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls |
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