Prognostic significance for recurrence of fibroblast growth factor receptor 2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection

Aims The fibroblast growth factor receptor 2 (FGFR2) fusion gene is frequently found as a genetic abnormality in the FGFR pathway in patients with intrahepatic cholangiocarcinoma (ICC). The FGFR fusion protein, produced from the FGFR fusion gene, is thought to cause tumor cell growth. To date, there...

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Published in:Hepatology research 2023-05, Vol.53 (5), p.432-439
Main Authors: Toshida, Katsuya, Itoh, Shinji, Yugawa, Kyohei, Kosai, Yukiko, Tomino, Takahiro, Yoshiya, Shohei, Nagao, Yoshihiro, Kayashima, Hiroto, Harada, Noboru, Kohashi, Kenichi, Oda, Yoshinao, Yoshizumi, Tomoharu
Format: Article
Language:English
Subjects:
Carcinoembryonic antigen
Cholangiocarcinoma
Fibroblast growth factor receptor 2
Fibroblast growth factor receptors
Fibroblasts
Fusion protein
Growth factors
Hepatectomy
intrahepatic cholangiocarcinoma
Localization
Lymphocytes
Medical prognosis
Multivariate analysis
Tumors
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Summary:Aims The fibroblast growth factor receptor 2 (FGFR2) fusion gene is frequently found as a genetic abnormality in the FGFR pathway in patients with intrahepatic cholangiocarcinoma (ICC). The FGFR fusion protein, produced from the FGFR fusion gene, is thought to cause tumor cell growth. To date, there have been few reports on the relationship between pathologic FGFR2 expression and prognosis in patients who have undergone hepatectomy for ICC, and on the relationship between FGFR2 and tumor‐infiltrating lymphocytes (TILs). Methods and Results We enrolled 92 patients who underwent hepatectomy for ICC and performed immunohistochemical staining for FGFR2 and cluster of differentiation 8, and hematoxylin and eosin staining for evaluating TILSs. The relationships between the FGFR2 and clinicopathological characteristics and outcomes were analyzed, and patients were classified into positive (n = 18) and negative (n = 74) FGFR2 groups. The FGFR2‐positive group contained more men (p 
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.13875