Intrauterine androgen exposure impairs gonadal adipose tissue functions of adult female rats

Prenatal androgen exposure induces fetal programming leading to alterations in offspring health and phenotypes that resemble those seen in women with Polycystic Ovary Syndrome. It has been described that prenatal androgenization affects the reproductive axis and leads to metabolic and endocrine diso...

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Bibliographic Details
Published in:Theriogenology 2023-03, Vol.198, p.131-140
Main Authors: Ferrer, María José, Abruzzese, Giselle Adriana, Heber, María Florencia, Ferreira, Silvana Rocío, Campo Verde Arbocco, Fiorella, Motta, Alicia Beatriz
Format: Article
Language:English
Subjects:
Adipokines
Adipose Tissue
Androgens
Animals
Aromatase
Female
Gonadal adipocytes
Hyperandrogenism
Lipid metabolism
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - veterinary
PPARs
Pregnancy
Prenatal Exposure Delayed Effects - veterinary
Rats
Steroids
Triglycerides
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Summary:Prenatal androgen exposure induces fetal programming leading to alterations in offspring health and phenotypes that resemble those seen in women with Polycystic Ovary Syndrome. It has been described that prenatal androgenization affects the reproductive axis and leads to metabolic and endocrine disorders. Adipose tissue plays a crucial role in all these functions and is susceptible to programming effects. Particularly, gonadal adipose tissue is involved in reproductive functions, so dysfunctions in this tissue could be related to fertility alterations. We aimed to investigate the extent to which prenatal hyperandrogenization is able to alter the functionality of gonadal adipose tissue in female adult rats, including lipid metabolism, adipokines expression, and de novo synthesis of steroids. Pregnant rats were treated with 1 mg of testosterone from day 16 to day 19 of pregnancy, and female offspring were followed until 90 days of age, when they were euthanized. The prenatally hyperandrogenized (PH) female offspring displayed two phenotypes: irregular ovulatory (PHiov) and anovulatory (PHanov). Regarding lipid metabolism, both PH groups displayed disruptions in the main lipid pathways with altered levels of triglyceride and increased lipid peroxidation levels. In addition, we found that Peroxisome Proliferator-Activated Receptors (PPARs) alpha protein expression was decreased in both PH phenotypes (p 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2022.12.035