Fully-modelled blood-focused variable inversion times for 3D late gadolinium-enhanced imaging

Variable heart rate during single-cycle inversion-recovery Late Gadolinium-Enhanced (LGE) scanning degrades image quality, which can be mitigated using Variable Inversion Times (VTIs) in real-time response to R-R interval changes. We investigate in vivo and in simulations an extension of a single-cy...

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Bibliographic Details
Published in:Magnetic resonance imaging 2023-05, Vol.98, p.44-54
Main Authors: Allen, Jack J., Keegan, Jennifer, Mathew, George, Conway, Miriam, Jenkins, Sophie, Pennell, Dudley J., Nielles-Vallespin, Sonia, Gatehouse, Peter, Babu-Narayan, Sonya V.
Format: Article
Language:English
Subjects:
Arrhythmia
Atrial Fibrillation
Cardiac
Cicatrix
Contrast Media
Gadolinium
Humans
Imaging, Three-Dimensional - methods
Late gadolinium-enhanced (LGE) imaging
Magnetic Resonance Imaging - methods
Myocardium
Myocardium - pathology
Variable inversion time (VTI)
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Summary:Variable heart rate during single-cycle inversion-recovery Late Gadolinium-Enhanced (LGE) scanning degrades image quality, which can be mitigated using Variable Inversion Times (VTIs) in real-time response to R-R interval changes. We investigate in vivo and in simulations an extension of a single-cycle VTI method previously applied in 3D LGE imaging, that now fully models the longitudinal magnetisation (fmVTI). The VTI and fmVTI methods were used to perform 3D LGE scans for 28 3D LGE patients, with qualitative image quality scores assigned for left atrial wall clarity and total ghosting. Accompanying simulations of numerical phantom images were assessed in terms of ghosting of normal myocardium, blood, and myocardial scar. The numerical simulations for fmVTI showed a significant decrease in blood ghosting (VTI: 410 ± 710, fmVTI: 68 ± 40, p  0.7). Simulations indicated reduced ghosting with the fmVTI method, due to reduced Mz variability in the blood signal. However, other sources of phase-encode ghosting and blurring appeared to dominate and obscure this finding in the patient studies available. •An in vivo comparison of two Variable Inversion Time (VTI) methods for 3D LGE: VTI and fmVTI.•The fmVTI method reduced blood and scar ghosting in simulation.•Other sources of ghosting and blurring appeared to dominate in the patient studies available.
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2022.12.014