N6-methyladenosine in macrophage function: a novel target for metabolic diseases

N6-methyladenosine (m6A) is a dynamic and reversible epigenetic modification that is involved in systemic immune and metabolic regulation by targeting RNA metabolism.m6A level and methylation patterns are changed in metabolic diseases and metabolic disorders.m6A modification significantly affects ma...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2023-02, Vol.34 (2), p.66-84
Main Authors: Zhu, Xiao, Tang, HaoJun, Yang, Min, Yin, Kai
Format: Article
Language:English
Subjects:
Humans
macrophage
Macrophages - physiology
metabolic diseases
Metabolic Diseases - genetics
N6-methyladenosine
Non-alcoholic Fatty Liver Disease - genetics
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Summary:N6-methyladenosine (m6A) is a dynamic and reversible epigenetic modification that is involved in systemic immune and metabolic regulation by targeting RNA metabolism.m6A level and methylation patterns are changed in metabolic diseases and metabolic disorders.m6A modification significantly affects macrophage function from the perspective of their development, activation, polarization, pyroptosis, lipid uptake, and cholesterol efflux.Regulation of macrophage m6A homeostasis may be a novel therapeutic strategy for the treatment of metabolic diseases, such as atherosclerosis and nonalcoholic fatty liver disease. N6-methyladenosine (m6A) is one of the most prevalent internal transcriptional modifications. Evidence has highlighted changes in m6A in metabolic disorders and various metabolic diseases. However, the precise mechanisms of these m6A changes in such conditions are not understood. Macrophages are crucial for the innate immune system and exert either beneficial or harmful roles in metabolic disease. Notably, m6A was found to be closely related to macrophage phenotype and dysfunction. In this review, we summarize m6A in macrophage function from the perspective of macrophage development, activation, and polarization, pyroptosis, and metabolic disorders. Furthermore, we discuss how m6A-mediated macrophage function affects metabolic diseases, including atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Finally, we discuss challenges and prospects for m6A in macrophage and metabolic diseases with the aim of providing guidance for the treatment of metabolic diseases.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2022.12.006