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Radiological precursor lesions of lung squamous cell carcinoma: Early progression patterns and divergent volume doubling time between hilar and peripheral zones

This study investigated the early progression patterns of lung squamous cell carcinoma (SqCC) on computed tomography (CT) images. In total, 65 patients with SqCC who underwent surgical resection and two CT scans separated by an interval of at least 6 months were enrolled. We categorized the findings...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2023-02, Vol.176, p.31-37
Main Authors: Sugawara, Haruto, Yatabe, Yasushi, Watanabe, Hirokazu, Akai, Hiroyuki, Abe, Osamu, Watanabe, Shun-ichi, Kusumoto, Masahiko
Format: Article
Language:English
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Summary:This study investigated the early progression patterns of lung squamous cell carcinoma (SqCC) on computed tomography (CT) images. In total, 65 patients with SqCC who underwent surgical resection and two CT scans separated by an interval of at least 6 months were enrolled. We categorized the findings of the initial and at-diagnosis CT images into five patterns as previously reported. The volume doubling time (VDT) was calculated for measurable lesions. A single nodule pattern on CT images at-diagnosis was most common in 56 (86.2 %) patients, in line with practical clinical findings. However, the patterns were diverse in the initial images, with 28 (43.1 %) patients displaying atypical findings, including multiple nodules (3.1 %), endobronchial lesions (20.0 %), subsolid nodules (10.8 %), and cyst wall thickening (9.2 %). All endobronchial lesions were located in the central/middle zone of the lung field, whereas lesions presented as multiple nodules, subsolid nodules, and cyst wall thickening were predominantly observed in the peripheral zone. The differences in the developed zones were reflected in the median VDT, and the tumors with an initial endobronchial pattern had a significantly shorter VDT than those with a subsolid nodule pattern (median: 140 days vs 276 days, p 
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2022.12.007