Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer

Transglutaminase-4, also known as prostate transglutaminase, is a protein encoded by the TGM4 gene. TGase-4 was thought to be exclusively expressed in the prostate gland and has been suggested to be involved in certain medical conditions, such as infertility and possibly prostate cancer. In recent y...

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Bibliographic Details
Published in:Anticancer research 2023-01, Vol.43 (1), p.291-296
Main Authors: Ye, Lin, Sanders, Andrew J, Jiang, Wen G
Format: Article
Language:English
Subjects:
Humans
Infertility
Male
Prognosis
Prostate
Prostate - metabolism
Prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - genetics
Proteins
Transglutaminases - metabolism
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Summary:Transglutaminase-4, also known as prostate transglutaminase, is a protein encoded by the TGM4 gene. TGase-4 was thought to be exclusively expressed in the prostate gland and has been suggested to be involved in certain medical conditions, such as infertility and possibly prostate cancer. In recent years, substantial progress has been made in the understanding of this unique protein in prostate cancer, with emerging clinical evidence. The present concise review summarised the current understanding of this intriguing enzyme in prostate cancer and presents an argument that TGase-4 is a useful indicator of both the development and progression of the disease.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.16162