Factor Analysis of Intraoperative Bleeding Loss and its Impact on Prognosis in Breast Cancer

• Published in: Anticancer research 2023-01, Vol.43 (1), p.191-200
• Main Authors: Takada, Koji, Kashiwagi, Shinichiro, Iimori, Nozomi, Kouhashi, Rika, Yabumoto, Akimichi, Goto, Wataru, Asano, Yuka, Tauchi, Yukie, Ogisawa, Kana, Morisaki, Tamami, Shibutani, Masatsune, Tanaka, Hiroaki, Maeda, Kiyoshi
• Format: Article
• Language: English
• Subjects: Blood Loss, Surgical; Breast cancer; Breast Neoplasms - pathology; Chemotherapy; Chi-square test; Diabetes mellitus; ErbB-2 protein; Factor analysis; Factor Analysis, Statistical; Female; Humans; Lymph nodes; Mastectomy - adverse effects; Medical prognosis; Patients; Prognosis; Rank tests; Regression analysis; Retrospective Studies; Statistical models; Survival
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.16149

Intraoperative blood loss (IBL) during the surgical treatment of various cancers affects complication rates and prognosis. However, few studies have examined the importance of minimal IBL in breast cancer surgery. We used factor analysis to examine the prognostic importance of IBL in breast cancer. One hundred ninety-seven patients who underwent mastectomy plus axillary lymph node dissection (level II) after preoperative chemotherapy between June 2007 and June 2021 were included. Pearson's Chi-square test was used to confirm the relationships between different factors. Kaplan-Meier survival curves and the log-rank test were used to examine prognosis. Logistic regression was performed using a Cox proportional hazards model. The median IBL was 55.0 g (range=5.0-420.0 g). IBL was 200 g in 15 patients (7.6%). Logistic regression analysis showed that patients with IBL ≥200 g had a significantly worse prognosis (disease-free survival: p=0.003, log-rank test; overall survival: p