Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers

Background. People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study...

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Published in:Environmental research 2023-03, Vol.220, p.115195-115195, Article 115195
Main Authors: Khan, Sosan Andleeb, Leonel Javeres, Mbah Ntepe, Abbas Shah, Syed Tahir, Bibi, Nazia, Muneer, Zahid, Hussain, Sabir, Nepovimova, Eugenie, Kuca, Kamil, Nurulain, Syed Muhammad
Format: Article
Language:English
Subjects:
Butyrylcholinesterase
Butyrylcholinesterase - genetics
Cytokines - genetics
Gasoline
Humans
Interleukin-6
K-variant
Occupational environment
Polymorphism, Single Nucleotide
Pro-inflammatory cytokines
Xenobiotics
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Summary:Background. People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study aimed to find the status and role of BChE in seven different occupational groups; gasoline fillers, auto-mechanics, carpenters, textile shop workers, furniture shop workers, electricians, and office workers. Methods. A total of 400 samples were screened. BChE activity was determined by Worek et al. method based on Ellman's principle. Pro-inflammatory cytokines were determined by ELISA. Genotypic analysis of the K-variant of BCHE gene SNP was carried out by standard molecular methods. Among seven groups, office workers were taken as a control to compare the results with all other occupational groups. Results. The results revealed a significant decrease in BChE activity in gasoline fillers (79.52%) followed by carpenters (73.49%), auto mechanics (39.76%), textile shop workers (18.07%), electricians (10.84%), and furniture shop workers (7.23%). TNF-α, IL-6, and IL1-β were elevated in all groups. IL-6 and IL1-β in gasoline fillers, and electricians were not statistically significantly increased. Binomial regression to determine the odd ratio was found to be significant (p 
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2022.115195