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Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers
Background. People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study...
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| Published in: | Environmental research 2023-03, Vol.220, p.115195-115195, Article 115195 |
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| creator | Khan, Sosan Andleeb Leonel Javeres, Mbah Ntepe Abbas Shah, Syed Tahir Bibi, Nazia Muneer, Zahid Hussain, Sabir Nepovimova, Eugenie Kuca, Kamil Nurulain, Syed Muhammad |
| description | Background.
People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study aimed to find the status and role of BChE in seven different occupational groups; gasoline fillers, auto-mechanics, carpenters, textile shop workers, furniture shop workers, electricians, and office workers.
Methods.
A total of 400 samples were screened. BChE activity was determined by Worek et al. method based on Ellman's principle. Pro-inflammatory cytokines were determined by ELISA. Genotypic analysis of the K-variant of BCHE gene SNP was carried out by standard molecular methods. Among seven groups, office workers were taken as a control to compare the results with all other occupational groups.
Results.
The results revealed a significant decrease in BChE activity in gasoline fillers (79.52%) followed by carpenters (73.49%), auto mechanics (39.76%), textile shop workers (18.07%), electricians (10.84%), and furniture shop workers (7.23%). TNF-α, IL-6, and IL1-β were elevated in all groups. IL-6 and IL1-β in gasoline fillers, and electricians were not statistically significantly increased. Binomial regression to determine the odd ratio was found to be significant (p |
| doi_str_mv | 10.1016/j.envres.2022.115195 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2760547521</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0013935122025221</els_id><sourcerecordid>2760547521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-3db2f60697b3102e47110d8ffe7a46abd31eeac7735e128582049a097099c7283</originalsourceid><addsrcrecordid>eNp9kEFv1DAQhS0EokvhHyDkI4dm8dhxHF-QYCktUgVIwNlynEnxNom3dtIq_x5vUzhyGo303pt5HyGvgW2BQfVuv8XxLmLacsb5FkCClk_IBpiuCqaleEo2jIEotJBwQl6ktM8rSMGekxNRSc1rpjfk_tOSIl7PvZ18GGnoaDNPS1x69zv0fsQ0YbQJz-jH3eU5vcYR6Y-v32lMUDPBVXlG7djSQwyFH7veDoOdQlyoW6Zwc7RTn0Odmw8P-ban9yHeYEwvybPO9glfPc5T8uvz-c_dZXH17eLL7sNV4QTAVIi24V3FKq0aAYxjqQBYW3cdKltWtmkFIFqnlJAIvJY1Z6W2TCumtVO8Fqfk7ZqbX7ydcx0z-OSw7-2IYU6Gq4rJUkkOWVquUhdDylA6c4h-sHExwMwRudmbFbk5Ijcr8mx783hhbgZs_5n-Ms6C96sAc887j9Ek53F02PqIbjJt8P-_8AeW9pQP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2760547521</pqid></control><display><type>article</type><title>Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers</title><source>ScienceDirect Journals</source><creator>Khan, Sosan Andleeb ; Leonel Javeres, Mbah Ntepe ; Abbas Shah, Syed Tahir ; Bibi, Nazia ; Muneer, Zahid ; Hussain, Sabir ; Nepovimova, Eugenie ; Kuca, Kamil ; Nurulain, Syed Muhammad</creator><creatorcontrib>Khan, Sosan Andleeb ; Leonel Javeres, Mbah Ntepe ; Abbas Shah, Syed Tahir ; Bibi, Nazia ; Muneer, Zahid ; Hussain, Sabir ; Nepovimova, Eugenie ; Kuca, Kamil ; Nurulain, Syed Muhammad</creatorcontrib><description>Background.
People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study aimed to find the status and role of BChE in seven different occupational groups; gasoline fillers, auto-mechanics, carpenters, textile shop workers, furniture shop workers, electricians, and office workers.
Methods.
A total of 400 samples were screened. BChE activity was determined by Worek et al. method based on Ellman's principle. Pro-inflammatory cytokines were determined by ELISA. Genotypic analysis of the K-variant of BCHE gene SNP was carried out by standard molecular methods. Among seven groups, office workers were taken as a control to compare the results with all other occupational groups.
Results.
The results revealed a significant decrease in BChE activity in gasoline fillers (79.52%) followed by carpenters (73.49%), auto mechanics (39.76%), textile shop workers (18.07%), electricians (10.84%), and furniture shop workers (7.23%). TNF-α, IL-6, and IL1-β were elevated in all groups. IL-6 and IL1-β in gasoline fillers, and electricians were not statistically significantly increased. Binomial regression to determine the odd ratio was found to be significant (p < 0.05) in all groups. However, correlation (Pearson) did not reveal significance between different biochemical parameters. Genotypic analysis of the K-variant SNP of the BCHE gene showed a significant association with occupational groups when compared with control which indicates a possible association with xenobiotics exposure and the physiological role of K-variant in understudied occupational groups.
Conclusion.
The study concluded that BChE and its gene SNP rs 1803274 and proinflammatory cytokines significantly dysregulates under the exposure to cumulative multiple xenobiotics in different occupational groups which may lead to pathophysiological conditions.
[Display omitted]
•A mixture of xenobiotics in different occupational environments affects the butyrylcholinesterase activity.•K-variant of the BCHE gene has a tentative association with the mixture of contaminants of the occupational environment.•Pro-inflammatory cytokines dysregulate variedly in different occupational environments xenobiotic which may lead to systemic inflammation.•The occupational environment needs regular surveillance and assessment of health risks due to chronic exposure to occupational contaminants/xenobiotics.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2022.115195</identifier><identifier>PMID: 36592809</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Butyrylcholinesterase ; Butyrylcholinesterase - genetics ; Cytokines - genetics ; Gasoline ; Humans ; Interleukin-6 ; K-variant ; Occupational environment ; Polymorphism, Single Nucleotide ; Pro-inflammatory cytokines ; Xenobiotics</subject><ispartof>Environmental research, 2023-03, Vol.220, p.115195-115195, Article 115195</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-3db2f60697b3102e47110d8ffe7a46abd31eeac7735e128582049a097099c7283</cites><orcidid>0000-0001-6146-1511 ; 0000-0002-2273-2697 ; 0000-0001-9151-9374 ; 0000-0001-9664-1109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36592809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Sosan Andleeb</creatorcontrib><creatorcontrib>Leonel Javeres, Mbah Ntepe</creatorcontrib><creatorcontrib>Abbas Shah, Syed Tahir</creatorcontrib><creatorcontrib>Bibi, Nazia</creatorcontrib><creatorcontrib>Muneer, Zahid</creatorcontrib><creatorcontrib>Hussain, Sabir</creatorcontrib><creatorcontrib>Nepovimova, Eugenie</creatorcontrib><creatorcontrib>Kuca, Kamil</creatorcontrib><creatorcontrib>Nurulain, Syed Muhammad</creatorcontrib><title>Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Background.
People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study aimed to find the status and role of BChE in seven different occupational groups; gasoline fillers, auto-mechanics, carpenters, textile shop workers, furniture shop workers, electricians, and office workers.
Methods.
A total of 400 samples were screened. BChE activity was determined by Worek et al. method based on Ellman's principle. Pro-inflammatory cytokines were determined by ELISA. Genotypic analysis of the K-variant of BCHE gene SNP was carried out by standard molecular methods. Among seven groups, office workers were taken as a control to compare the results with all other occupational groups.
Results.
The results revealed a significant decrease in BChE activity in gasoline fillers (79.52%) followed by carpenters (73.49%), auto mechanics (39.76%), textile shop workers (18.07%), electricians (10.84%), and furniture shop workers (7.23%). TNF-α, IL-6, and IL1-β were elevated in all groups. IL-6 and IL1-β in gasoline fillers, and electricians were not statistically significantly increased. Binomial regression to determine the odd ratio was found to be significant (p < 0.05) in all groups. However, correlation (Pearson) did not reveal significance between different biochemical parameters. Genotypic analysis of the K-variant SNP of the BCHE gene showed a significant association with occupational groups when compared with control which indicates a possible association with xenobiotics exposure and the physiological role of K-variant in understudied occupational groups.
Conclusion.
The study concluded that BChE and its gene SNP rs 1803274 and proinflammatory cytokines significantly dysregulates under the exposure to cumulative multiple xenobiotics in different occupational groups which may lead to pathophysiological conditions.
[Display omitted]
•A mixture of xenobiotics in different occupational environments affects the butyrylcholinesterase activity.•K-variant of the BCHE gene has a tentative association with the mixture of contaminants of the occupational environment.•Pro-inflammatory cytokines dysregulate variedly in different occupational environments xenobiotic which may lead to systemic inflammation.•The occupational environment needs regular surveillance and assessment of health risks due to chronic exposure to occupational contaminants/xenobiotics.</description><subject>Butyrylcholinesterase</subject><subject>Butyrylcholinesterase - genetics</subject><subject>Cytokines - genetics</subject><subject>Gasoline</subject><subject>Humans</subject><subject>Interleukin-6</subject><subject>K-variant</subject><subject>Occupational environment</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pro-inflammatory cytokines</subject><subject>Xenobiotics</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEFv1DAQhS0EokvhHyDkI4dm8dhxHF-QYCktUgVIwNlynEnxNom3dtIq_x5vUzhyGo303pt5HyGvgW2BQfVuv8XxLmLacsb5FkCClk_IBpiuCqaleEo2jIEotJBwQl6ktM8rSMGekxNRSc1rpjfk_tOSIl7PvZ18GGnoaDNPS1x69zv0fsQ0YbQJz-jH3eU5vcYR6Y-v32lMUDPBVXlG7djSQwyFH7veDoOdQlyoW6Zwc7RTn0Odmw8P-ban9yHeYEwvybPO9glfPc5T8uvz-c_dZXH17eLL7sNV4QTAVIi24V3FKq0aAYxjqQBYW3cdKltWtmkFIFqnlJAIvJY1Z6W2TCumtVO8Fqfk7ZqbX7ydcx0z-OSw7-2IYU6Gq4rJUkkOWVquUhdDylA6c4h-sHExwMwRudmbFbk5Ijcr8mx783hhbgZs_5n-Ms6C96sAc887j9Ek53F02PqIbjJt8P-_8AeW9pQP</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Khan, Sosan Andleeb</creator><creator>Leonel Javeres, Mbah Ntepe</creator><creator>Abbas Shah, Syed Tahir</creator><creator>Bibi, Nazia</creator><creator>Muneer, Zahid</creator><creator>Hussain, Sabir</creator><creator>Nepovimova, Eugenie</creator><creator>Kuca, Kamil</creator><creator>Nurulain, Syed Muhammad</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6146-1511</orcidid><orcidid>https://orcid.org/0000-0002-2273-2697</orcidid><orcidid>https://orcid.org/0000-0001-9151-9374</orcidid><orcidid>https://orcid.org/0000-0001-9664-1109</orcidid></search><sort><creationdate>20230301</creationdate><title>Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers</title><author>Khan, Sosan Andleeb ; Leonel Javeres, Mbah Ntepe ; Abbas Shah, Syed Tahir ; Bibi, Nazia ; Muneer, Zahid ; Hussain, Sabir ; Nepovimova, Eugenie ; Kuca, Kamil ; Nurulain, Syed Muhammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-3db2f60697b3102e47110d8ffe7a46abd31eeac7735e128582049a097099c7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Butyrylcholinesterase</topic><topic>Butyrylcholinesterase - genetics</topic><topic>Cytokines - genetics</topic><topic>Gasoline</topic><topic>Humans</topic><topic>Interleukin-6</topic><topic>K-variant</topic><topic>Occupational environment</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pro-inflammatory cytokines</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Sosan Andleeb</creatorcontrib><creatorcontrib>Leonel Javeres, Mbah Ntepe</creatorcontrib><creatorcontrib>Abbas Shah, Syed Tahir</creatorcontrib><creatorcontrib>Bibi, Nazia</creatorcontrib><creatorcontrib>Muneer, Zahid</creatorcontrib><creatorcontrib>Hussain, Sabir</creatorcontrib><creatorcontrib>Nepovimova, Eugenie</creatorcontrib><creatorcontrib>Kuca, Kamil</creatorcontrib><creatorcontrib>Nurulain, Syed Muhammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Sosan Andleeb</au><au>Leonel Javeres, Mbah Ntepe</au><au>Abbas Shah, Syed Tahir</au><au>Bibi, Nazia</au><au>Muneer, Zahid</au><au>Hussain, Sabir</au><au>Nepovimova, Eugenie</au><au>Kuca, Kamil</au><au>Nurulain, Syed Muhammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>220</volume><spage>115195</spage><epage>115195</epage><pages>115195-115195</pages><artnum>115195</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><abstract>Background.
People in different occupations are exposed to a variety of xenobiotics which affect the health and physiological processes of the body. Butyrylcholinesterase (BChE), has been reported to play neuronal and non-neuronal roles, though its exact function is yet to be established. This study aimed to find the status and role of BChE in seven different occupational groups; gasoline fillers, auto-mechanics, carpenters, textile shop workers, furniture shop workers, electricians, and office workers.
Methods.
A total of 400 samples were screened. BChE activity was determined by Worek et al. method based on Ellman's principle. Pro-inflammatory cytokines were determined by ELISA. Genotypic analysis of the K-variant of BCHE gene SNP was carried out by standard molecular methods. Among seven groups, office workers were taken as a control to compare the results with all other occupational groups.
Results.
The results revealed a significant decrease in BChE activity in gasoline fillers (79.52%) followed by carpenters (73.49%), auto mechanics (39.76%), textile shop workers (18.07%), electricians (10.84%), and furniture shop workers (7.23%). TNF-α, IL-6, and IL1-β were elevated in all groups. IL-6 and IL1-β in gasoline fillers, and electricians were not statistically significantly increased. Binomial regression to determine the odd ratio was found to be significant (p < 0.05) in all groups. However, correlation (Pearson) did not reveal significance between different biochemical parameters. Genotypic analysis of the K-variant SNP of the BCHE gene showed a significant association with occupational groups when compared with control which indicates a possible association with xenobiotics exposure and the physiological role of K-variant in understudied occupational groups.
Conclusion.
The study concluded that BChE and its gene SNP rs 1803274 and proinflammatory cytokines significantly dysregulates under the exposure to cumulative multiple xenobiotics in different occupational groups which may lead to pathophysiological conditions.
[Display omitted]
•A mixture of xenobiotics in different occupational environments affects the butyrylcholinesterase activity.•K-variant of the BCHE gene has a tentative association with the mixture of contaminants of the occupational environment.•Pro-inflammatory cytokines dysregulate variedly in different occupational environments xenobiotic which may lead to systemic inflammation.•The occupational environment needs regular surveillance and assessment of health risks due to chronic exposure to occupational contaminants/xenobiotics.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>36592809</pmid><doi>10.1016/j.envres.2022.115195</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6146-1511</orcidid><orcidid>https://orcid.org/0000-0002-2273-2697</orcidid><orcidid>https://orcid.org/0000-0001-9151-9374</orcidid><orcidid>https://orcid.org/0000-0001-9664-1109</orcidid></addata></record> |
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| subjects | Butyrylcholinesterase Butyrylcholinesterase - genetics Cytokines - genetics Gasoline Humans Interleukin-6 K-variant Occupational environment Polymorphism, Single Nucleotide Pro-inflammatory cytokines Xenobiotics |
| title | Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers |
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