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CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice
Schwann cells are glial cells that myelinate neuronal axons in the peripheral nervous system (PNS). When the PNS is damaged, Schwann cells de-differentiate into p75-positive “repair Schwann cells,” which contribute to neural circuit regeneration. Interestingly, Schwann cells in the dorsal roots are...
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Published in: | Neuroscience research 2023-06, Vol.191, p.38-47 |
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description | Schwann cells are glial cells that myelinate neuronal axons in the peripheral nervous system (PNS). When the PNS is damaged, Schwann cells de-differentiate into p75-positive “repair Schwann cells,” which contribute to neural circuit regeneration. Interestingly, Schwann cells in the dorsal roots are known to be reprogrammed to repair Schwann cells even after spinal cord injury (SCI) and then migrate into the injured spinal cord. However, the molecular mechanism underlying the migration of repair Schwann cells remains unknown. Since a recent in vitro study revealed the importance of CXCR4 signaling in Schwann cell migration, we investigated whether CXCR4 signaling is involved in the PNS-to-central nervous system (CNS) migration of repair Schwann cells after SCI. We revealed that repair Schwann cells express CXCR4, and its ligand CXCL12 is upregulated in the injured spinal cord. We also found that the pharmacological inhibition of CXCR4 signaling decreased the infiltration of repair Schwann cells. Moreover, CXCR4 agonist administration effectively increased the infiltration of repair Schwann cells along with improved motor function. These findings strongly suggest the involvement of CXCR4 signaling in the PNS-to-CNS migration of repair Schwann cells after SCI.
•p75-positive “repair Schwann cells”, which migrate from the dorsal roots into the spinal cord after spinal cord injury, are distributed bimodally along the rostro-caudal axis of the spinal cord.•These repair Schwann cells express a chemokine receptor CXCR4.•CXCR4 signaling regulates the infiltration of repair Schwann cells into the injured spinal cord. |
doi_str_mv | 10.1016/j.neures.2022.12.022 |
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•p75-positive “repair Schwann cells”, which migrate from the dorsal roots into the spinal cord after spinal cord injury, are distributed bimodally along the rostro-caudal axis of the spinal cord.•These repair Schwann cells express a chemokine receptor CXCR4.•CXCR4 signaling regulates the infiltration of repair Schwann cells into the injured spinal cord.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2022.12.022</identifier><identifier>PMID: 36592826</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Axons - physiology ; CXCR4 ; Mice ; Nerve Regeneration - physiology ; Neuroglia - physiology ; p75 ; Repair Schwann cell ; Schwann Cells ; Signal Transduction - physiology ; Spinal Cord - physiology ; Spinal Cord Injuries ; Spinal cord injury</subject><ispartof>Neuroscience research, 2023-06, Vol.191, p.38-47</ispartof><rights>2023 Elsevier Ltd and Japan Neuroscience Society</rights><rights>Copyright © 2023 Elsevier Ltd and Japan Neuroscience Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-486f09b668689ab2a0d3cb12aefa9cc159deeb5e90bd2e1b1012f42e846f9bc13</citedby><cites>FETCH-LOGICAL-c432t-486f09b668689ab2a0d3cb12aefa9cc159deeb5e90bd2e1b1012f42e846f9bc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168010222003236$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36592826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furumiya, Takeru</creatorcontrib><creatorcontrib>Itokazu, Takahide</creatorcontrib><creatorcontrib>Nakanishi, Toru</creatorcontrib><creatorcontrib>Yamashita, Toshihide</creatorcontrib><title>CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>Schwann cells are glial cells that myelinate neuronal axons in the peripheral nervous system (PNS). When the PNS is damaged, Schwann cells de-differentiate into p75-positive “repair Schwann cells,” which contribute to neural circuit regeneration. Interestingly, Schwann cells in the dorsal roots are known to be reprogrammed to repair Schwann cells even after spinal cord injury (SCI) and then migrate into the injured spinal cord. However, the molecular mechanism underlying the migration of repair Schwann cells remains unknown. Since a recent in vitro study revealed the importance of CXCR4 signaling in Schwann cell migration, we investigated whether CXCR4 signaling is involved in the PNS-to-central nervous system (CNS) migration of repair Schwann cells after SCI. We revealed that repair Schwann cells express CXCR4, and its ligand CXCL12 is upregulated in the injured spinal cord. We also found that the pharmacological inhibition of CXCR4 signaling decreased the infiltration of repair Schwann cells. Moreover, CXCR4 agonist administration effectively increased the infiltration of repair Schwann cells along with improved motor function. These findings strongly suggest the involvement of CXCR4 signaling in the PNS-to-CNS migration of repair Schwann cells after SCI.
•p75-positive “repair Schwann cells”, which migrate from the dorsal roots into the spinal cord after spinal cord injury, are distributed bimodally along the rostro-caudal axis of the spinal cord.•These repair Schwann cells express a chemokine receptor CXCR4.•CXCR4 signaling regulates the infiltration of repair Schwann cells into the injured spinal cord.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>CXCR4</subject><subject>Mice</subject><subject>Nerve Regeneration - physiology</subject><subject>Neuroglia - physiology</subject><subject>p75</subject><subject>Repair Schwann cell</subject><subject>Schwann Cells</subject><subject>Signal Transduction - physiology</subject><subject>Spinal Cord - physiology</subject><subject>Spinal Cord Injuries</subject><subject>Spinal cord injury</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobk7_gUguvWlNTrusvRFk-AUDwQ_wLqTp6ZbRpTVJFf-9GVPBG6_eJDxvDuch5JSzlDMuLtapxcGhT4EBpBzSGHtkzIsZJAXnfJ-MI1YkjDMYkSPv14yxrMyzQzLKxLSEAsSY9PPX-WNOvVla1Rq7pA6XQ6sC-njqlXH0Sa8-lLVUY9tSYxvTBqeC6Wy8hI6GFVLfm9imunM1VU1A9-fF2PXgPmPQjdF4TA4a1Xo8-c4Jebm5fp7fJYuH2_v51SLReQYhyQvRsLISohBFqSpQrM50xUFho0qt-bSsEasplqyqAXkVlUCTAxa5aMpK82xCznf_9q57G9AHuTF-u4Oy2A1ewkywaT4TGUQ036Hadd47bGTvzEa5T8mZ3LqWa7lzLbeuJQcZI9bOvicM1Qbr39KP3Ahc7gCMe74bdNJrg1ZjbRzqIOvO_D_hC9zdk6Y</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Furumiya, Takeru</creator><creator>Itokazu, Takahide</creator><creator>Nakanishi, Toru</creator><creator>Yamashita, Toshihide</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202306</creationdate><title>CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice</title><author>Furumiya, Takeru ; Itokazu, Takahide ; Nakanishi, Toru ; Yamashita, Toshihide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-486f09b668689ab2a0d3cb12aefa9cc159deeb5e90bd2e1b1012f42e846f9bc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>CXCR4</topic><topic>Mice</topic><topic>Nerve Regeneration - physiology</topic><topic>Neuroglia - physiology</topic><topic>p75</topic><topic>Repair Schwann cell</topic><topic>Schwann Cells</topic><topic>Signal Transduction - physiology</topic><topic>Spinal Cord - physiology</topic><topic>Spinal Cord Injuries</topic><topic>Spinal cord injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furumiya, Takeru</creatorcontrib><creatorcontrib>Itokazu, Takahide</creatorcontrib><creatorcontrib>Nakanishi, Toru</creatorcontrib><creatorcontrib>Yamashita, Toshihide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furumiya, Takeru</au><au>Itokazu, Takahide</au><au>Nakanishi, Toru</au><au>Yamashita, Toshihide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2023-06</date><risdate>2023</risdate><volume>191</volume><spage>38</spage><epage>47</epage><pages>38-47</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>Schwann cells are glial cells that myelinate neuronal axons in the peripheral nervous system (PNS). When the PNS is damaged, Schwann cells de-differentiate into p75-positive “repair Schwann cells,” which contribute to neural circuit regeneration. Interestingly, Schwann cells in the dorsal roots are known to be reprogrammed to repair Schwann cells even after spinal cord injury (SCI) and then migrate into the injured spinal cord. However, the molecular mechanism underlying the migration of repair Schwann cells remains unknown. Since a recent in vitro study revealed the importance of CXCR4 signaling in Schwann cell migration, we investigated whether CXCR4 signaling is involved in the PNS-to-central nervous system (CNS) migration of repair Schwann cells after SCI. We revealed that repair Schwann cells express CXCR4, and its ligand CXCL12 is upregulated in the injured spinal cord. We also found that the pharmacological inhibition of CXCR4 signaling decreased the infiltration of repair Schwann cells. Moreover, CXCR4 agonist administration effectively increased the infiltration of repair Schwann cells along with improved motor function. These findings strongly suggest the involvement of CXCR4 signaling in the PNS-to-CNS migration of repair Schwann cells after SCI.
•p75-positive “repair Schwann cells”, which migrate from the dorsal roots into the spinal cord after spinal cord injury, are distributed bimodally along the rostro-caudal axis of the spinal cord.•These repair Schwann cells express a chemokine receptor CXCR4.•CXCR4 signaling regulates the infiltration of repair Schwann cells into the injured spinal cord.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36592826</pmid><doi>10.1016/j.neures.2022.12.022</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Axons - physiology CXCR4 Mice Nerve Regeneration - physiology Neuroglia - physiology p75 Repair Schwann cell Schwann Cells Signal Transduction - physiology Spinal Cord - physiology Spinal Cord Injuries Spinal cord injury |
title | CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice |
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