Changes in Tophus Composition During Urate‐Lowering Therapy: A Dual‐Energy Computed Tomography Study

Objective The gouty tophus is an organized structure composed of monosodium urate (MSU) crystals and chronic inflammatory soft tissue. This dual‐energy computed tomography (DECT) study aimed to determine whether the composition of the tophus changes during urate‐lowering therapy. Methods Serial DECT...

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Bibliographic Details
Published in:Arthritis care & research (2010) 2023-09, Vol.75 (9), p.1949-1954
Main Authors: Chen, Leanne, Gamble, Gregory D., Horne, Anne, Drake, Jill, Doyle, Anthony J., Uhlig, Till, Stamp, Lisa K., Dalbeth, Nicola
Format: Article
Language:English
Subjects:
Allopurinol
Computed tomography
Crystals
Gout
Inflammation
Tomography
Uric acid
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Summary:Objective The gouty tophus is an organized structure composed of monosodium urate (MSU) crystals and chronic inflammatory soft tissue. This dual‐energy computed tomography (DECT) study aimed to determine whether the composition of the tophus changes during urate‐lowering therapy. Methods Serial DECT scans from 32 people with gout were obtained over 2 years of allopurinol therapy, dose‐escalated to serum urate of
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.25084