Cognitive impairment in patients with heart failure: molecular mechanism and therapy

Heart failure (HF) is associated with multiple organ dysfunction and many comorbidities. Its incidence is high among the elderly and is a major health burden worldwide. Cognitive impairment (CI) is highly prevalent in older patients with HF, which is an abnormality in one or more of the items of cog...

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Bibliographic Details
Published in:Heart failure reviews 2023-07, Vol.28 (4), p.807-820
Main Authors: Wu, Yanan, Chen, Liwen, Zhong, Feng, Zhou, Kaiyi, Lu, Chao, Cheng, Xiao, Wang, Sheng
Format: Article
Language:English
Subjects:
Acuity
Cardiology
Cognition
Cognitive ability
Comorbidity
Congestive heart failure
Epidemiology
Heart failure
Medicine
Medicine & Public Health
Molecular modelling
Risk factors
Visual perception
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Summary:Heart failure (HF) is associated with multiple organ dysfunction and many comorbidities. Its incidence is high among the elderly and is a major health burden worldwide. Cognitive impairment (CI) is highly prevalent in older patients with HF, which is an abnormality in one or more of the items of cognition, attention, memory, language, psychomotor function, and visual spatial acuity. Studies have shown that the incidence of CI in HF patients is between 13 and 54%, and patients with both conditions have poor self-care ability and prognosis, as well as increased mortality rates. However, the mechanisms of CI development in HF patients are still unclear. In this review, we describe the epidemiology and risk factors as well as measures of improving CI in HF patients. We update the latest pathophysiological mechanisms related to the neurocognitive changes in HF patients, expounding on the mechanisms associated with the development of CI in HF patients.
ISSN:1573-7322
1382-4147
1573-7322
DOI:10.1007/s10741-022-10289-9