Comparative anti-herpes simplex virus type 1 and chemical profiling of Thymus capitatus and Artemisia herba-alba collected from North Africa

Herpes simplex virus (HSV) can infect millions of people worldwide causing mild to life-threating infections. The current study demonstrates the first comparative anti-HSV type 1 activity and phytochemical investigation of and collected from Egypt and Libya. Liquid chromatography/mass spectrometry (...

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Bibliographic Details
Published in:Natural product research 2023-12, Vol.37 (23), p.1-4041
Main Authors: Mohyeldin, Mohamed M, Tarbah, Ahmaida F S, El-Deeb, Nehal M, Ghazy, Nabila M, El-Hawiet, Amr
Format: Article
Language:English
Subjects:
Artemisia herba-alba
Chromatography
Essential oils
Flavonoids
Gas chromatography
Herpes simplex
Herpes viruses
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Monoterpenes
Phenolic acids
Phenols
Scientific imaging
Thymus capitatus
Thymus gland
Viruses
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Summary:Herpes simplex virus (HSV) can infect millions of people worldwide causing mild to life-threating infections. The current study demonstrates the first comparative anti-HSV type 1 activity and phytochemical investigation of and collected from Egypt and Libya. Liquid chromatography/mass spectrometry (LC/MS) analysis allowed the identification of 56 and 38 compounds in the Egyptian and Libyan ethanolic extracts, respectively, in addition to 46 and 50 compounds in the Egyptian and Libyan ethanolic extracts, respectively. Gas chromatography/mass spectrometry (GC/MS) analysis of their corresponding essential oils revealed the presence of 15, 17, 17 and 8 compounds in Egyptian and Libyan and respectively. The major chemical classes of the identified compounds were phenolic acids, flavonoids and oxygenated monoterpenes. Evaluation of the anti-HSV1 activities of the studied extracts showed that the Egyptian ethanolic extracts were the most potent extract with more than 200-fold reduction in the viral PFU.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2164280