Head-to-head comparison of [68Ga]Ga-P16-093 and 2-[18F]FDG PET/CT in patients with clear cell renal cell carcinoma: a pilot study

• Published in: European journal of nuclear medicine and molecular imaging 2023-04, Vol.50 (5), p.1499-1509
• Main Authors: Wang, Guochang, Li, Linlin, Wang, Jiarou, Zang, Jie, Chen, Jingci, Xiao, Yu, Fan, Xinrong, Zhu, Lin, Kung, Hank F., Zhu, Zhaohui
• Format: Article
• Language: English
• Subjects: Carcinoma, Renal Cell - diagnostic imaging; Cardiology; Fluorodeoxyglucose F18 - metabolism; Gallium Radioisotopes; Humans; Imaging; Kidney Neoplasms - diagnostic imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Oncology – Genitourinary; Original Article; Orthopedics; Pilot Projects; Positron Emission Tomography Computed Tomography - methods; Radiology
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-022-06101-3

Purpose This pilot study was prospectively designed to evaluate and compare the diagnostic value of PET/CT using a PSMA-specific tracer [ 68 Ga]Ga-P16-093 and a glucose metabolism probe 2-[ 18 F]FDG in clear cell renal cell carcinoma (ccRCC) patients. Methods Forty-two pathologically confirmed ccRCC patients were included. Within 1 week, each patient underwent [ 68 Ga]Ga-P16-093 and 2-[ 18 F]FDG PET/CT. In addition to visual analysis of tumor number, the standardized uptake value (SUV) was measured for semiquantitative comparison and correlation analysis. Results For primary ccRCC patients, [ 68 Ga]Ga-P16-093 PET/CT demonstrated a significantly higher detection rate (19/22 vs . 13/22, P  = 0.031) and higher tumor uptake (15.7 ± 9.0 vs . 5.1 ± 3.4, P