Creatine chemical exchange saturation transfer (CEST) CMR imaging reveals myocardial early involvement in idiopathic inflammatory myopathy at 3T: feasibility and initial experience

• Published in: European radiology 2023-06, Vol.33 (6), p.3897-3907
• Main Authors: Fan, Zi-Yang, Lin, Yan-Wei, Shi, Ruo-Yang, Yu, Ling-Zhan, Wu, Rui, Yao, Qiu-Ying, Wesemann, Luke D., Hu, Jiani, Liu, Qi, Zhou, Yan, Chen, Sheng, Wu, Lian-Ming
• Format: Article
• Language: English
• Subjects: Adenosine triphosphate; Cardiac; Contrast Media; Creatine; Diagnostic Radiology; Disease; Ejection fraction; Feasibility Studies; Heart; Heart failure; Humans; Imaging; Inflammation; Inflammatory diseases; Internal Medicine; Interventional Radiology; Kinases; Magnetic resonance; Magnetic Resonance Imaging, Cine - methods; Male; Males; Mapping; Medicine; Medicine & Public Health; Metabolites; Musculoskeletal diseases; Myocardium; Myocardium - pathology; Myopathy; Myositis - diagnostic imaging; Myositis - pathology; Neuroradiology; Predictive Value of Tests; Radiology; Segments; Subgroups; Troponin; Troponin T; Ultrasound; Variance analysis
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-022-09363-5

Objectives To measure creatine distribution in idiopathic inflammatory myopathy (IIM) patients’ myocardial segments and investigate whether cardiovascular magnetic resonance (CMR) chemical exchange saturation transfer (CEST) creatine mapping can detect subclinical myocardial changes, CEST’s ability was further compared with other conventional CMR mapping sequences. Methods Forty IIM patients (53.5 ± 10.5 years, 26 males) and eight healthy controls (35.4 ± 6 years, 5 males) underwent CMR scans on a 3.0-T MR scanner. Patients with IIM were further classified into two subgroups according to cardiac troponin T (cTn-T) values: the elevated cTn-T subgroup ( n = 14) and the normal cTn-T subgroup ( n = 26). Cine imaging, T2 SPAIR, LGE imaging, T1 mapping, T2 mapping, and Cr (creatine) CEST were performed. Results Cr mapping showed significantly reduced creatine in IIM patients among global myocardium (IIM: 0.109 ± 0.063, controls: 0.121 ± 0.021, p < 0.05), and decreased creatine signals were detected in all 16 cardiac segments ( p < 0.05). Patients also had significantly prolonged native T1 and decreased enhanced T1 values in each cardiac segment ( p < 0.05). There was no significant difference of LVEF and T2 values between IIM patients and controls. Between the two subgroups, elevated cTn-T was linked with creatine and extracellular volume fraction (ECV) values, providing a global average creatine signal of 0.107 vs 0.112 ( p < 0.05) and 24.7 vs 32.4 ( p < 0.05). Conclusion Creatine CEST mapping can detect early-stage heart involvement with negative LGE findings in IIM. Compared with T1 mapping, CEST provides increased sensitivity to ECV measurement, making it significantly better than T1, and a promising CMR sequence for screening subclinical myocardial damage. Key Points • IIM patients with potential or ongoing heart involvement, elevated ECV, and reduced Cr CEST values could provide valuable information. • ECV and Cr CEST values were closely related to elevated cTn-T.