A fiducial approach for testing the non‐inferiority of proportion difference in matched‐pairs design

The non‐inferiority of one treatment/drug to another is a common and important issue in medical and pharmaceutical fields. This study explored a fiducial approach for testing the non‐inferiority of proportion difference in matched‐pairs design. Approximate tests constructed using fiducial quantities...

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Bibliographic Details
Published in:Pharmaceutical statistics : the journal of the pharmaceutical industry 2023-05, Vol.22 (3), p.520-530
Main Authors: Chen, Chao, Ye, Siyang, Xu, Jiahao, Wan, Kai, Chen, Yanting
Format: Article
Language:English
Subjects:
Computer Simulation
difference
fiducial
Humans
matched‐pairs design
non‐inferiority
Pharmaceuticals
Research Design
Statistical analysis
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Summary:The non‐inferiority of one treatment/drug to another is a common and important issue in medical and pharmaceutical fields. This study explored a fiducial approach for testing the non‐inferiority of proportion difference in matched‐pairs design. Approximate tests constructed using fiducial quantities with a combination of different parameters were proposed. Four simulation studies were employed to compare the performance of fiducial tests by comparing their type I errors and powers. The results showed that fiducial quantities with parameter 0.6≤w1≤0.8 performed satisfactorily from small to large samples. Therefore, the fiducial tests could be recommended for practical applications. The recommended fiducial tests might be a competitive alternative to other available tests. Three real data sets were analyzed to illustrate the proposed methods were competitive or even better than other tests.
ISSN:1539-1604
1539-1612
DOI:10.1002/pst.2288