Bioinspired Polyethylene Glycol Coatings for Reduced Nanoparticle–Protein Interactions

Nanoparticles (NPs) and other engineered nanomaterials have great potential as nanodrugs or nanomedical devices for biomedical applications. However, the adsorption of proteins in blood circulation or similar physiological fluids can significantly alter the surface properties and therapeutic respons...

Full description

Saved in:
Bibliographic Details
Published in:ACS nano 2023-01, Vol.17 (2), p.955-965
Main Authors: Toro-Mendoza, Jhoan, Maio, Lucia, Gallego, Marta, Otto, Ferdinand, Schulz, Florian, Parak, Wolfgang J., Sanchez-Cano, Carlos, Coluzza, Ivan
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanoparticles (NPs) and other engineered nanomaterials have great potential as nanodrugs or nanomedical devices for biomedical applications. However, the adsorption of proteins in blood circulation or similar physiological fluids can significantly alter the surface properties and therapeutic response induced by most nanomaterials. For example, interaction with proteins can change the bloodstream circulation time and availability of therapeutic NPs or hinder the accumulation in their desired target organs. Proteins can also trigger or prevent agglomeration. By combining experimental and computational approaches, we have developed NPs carrying polyethylene glycol (PEG) polymeric coatings that mimic the surface charge distribution of proteins typically found in blood, which are known to show low aggregation under normal blood conditions. Here, we show that NPs with coatings based on apoferritin or human serum albumin display better antifouling properties and weaker protein interaction compared to similar NPs carrying conventional PEG polymeric coatings.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.2c05682