A case of hypogonadtropic hypogonadism due to hypophysitis discovered by secondary male infertility

• Published in: IJU case reports 2023, Vol.6 (1), p.51-53
• Main Authors: Konishi, Masatoshi, Maegawa, Yoko, Tani, Masaru, Asakura, Toshihisa, Hayashi, Yujiro, Kakuta, Yoichi, Tsutahara, Koichi, Komori, Kazuhiko, Takao, Tetsuya
• Format: Report
• Language: English
• ISSN: 2577-171X
• DOI: 10.1002/iju5.12548

IntroductionThe main causes of secondary male infertility are varicocele and aging. It is rarely caused by adult-onset hypopituitarism. The onset of hypopituitarism is often due to brain tumors, trauma, surgery, or congenital disorders. Case presentationA 29-year-old man was admitted to the hospital with complaints of decreased libido and semen volume, which lasted for 4 months. He had no abnormalities in adolescence and has a 2-year-old child. Blood tests showed low luteinizing hormone and follicle-stimulating hormone, and semen tests showed azoospermia. Magnetic resonance imaging T1-weighted images showed swelling and enhancement effect of the pituitary gland, and lymphocytic hypophysitis was suspected. After an Insulin-thyroid-stimulating hormone releasing hormone-luteinizing hormone-releasing hormone test, a decrease in luteinizing hormone/follicle-stimulating hormone secretion was considered. We diagnosed hypogonadotropic hypogonadism due to lymphocytic hypophysitis. Currently, the patient is being treated with a hormone replacement therapy. ConclusionWe experienced a case of hypogonadotropic hypogonadism due to lymphocytic hypophysitis discovered by secondary infertility.