Effect of Leflunomide Use on 68Ga-DOTATATE Biodistribution in a Case With Neuroendocrine Tumor

A 58-year-old man who underwent surgery for a well-differentiated neuroendocrine tumor of pancreatic origin was evaluated with 68Ga-DOTATATE PET/CT imaging in the follow-up period. After PET/CT findings consistent with disease remission, the patient was started on leflunomide treatment with the diag...

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Bibliographic Details
Published in:Clinical nuclear medicine 2023-02, Vol.48 (2), p.e71-e73
Main Authors: Tatar, Gamze, Beyhan, Ediz, Arslan, Esra, Ergül, Nurhan, Çermik, Tevfik Fikret
Format: Article
Language:English
Subjects:
Humans
Leflunomide - therapeutic use
Male
Middle Aged
Neuroendocrine Tumors - pathology
Organometallic Compounds - therapeutic use
Positron Emission Tomography Computed Tomography - methods
Tissue Distribution
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Summary:A 58-year-old man who underwent surgery for a well-differentiated neuroendocrine tumor of pancreatic origin was evaluated with 68Ga-DOTATATE PET/CT imaging in the follow-up period. After PET/CT findings consistent with disease remission, the patient was started on leflunomide treatment with the diagnosis of rheumatoid arthritis. The patient received leflunomide for 6 months. Then, 68Ga-DOTATATE PET/CT scan was repeated to evaluate the primary disease outcome. Besides the disease remission, we also observed alterations in DOTATATE uptakes of some tissues and organs. In this case, we present the changes in 68Ga-DOTATATE PET/CT scan findings after leflunomide use.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000004517