Role of nucleic acid-based polymeric micelles in treating lung diseases

The prevalence of lung diseases is increasing year by year and existing drug therapies only provide symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative therapeutic approach owing to their potential to reform a homeostatic balance by upregulating pro...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2022-10, Vol.17 (25), p.1951-1960
Main Authors: Kaur, Jaskiran, Gulati, Monica, Corrie, Leander, Awasthi, Ankit, Jha, Niraj Kumar, Chellappan, Dinesh Kumar, Gupta, Gaurav, MacLoughlin, Ronan, Oliver, Brian G, Dua, Kamal, Singh, Sachin Kumar
Format: Article
Language:English
Subjects:
Biological Transport
Drug Carriers - chemistry
Drug Delivery Systems
functionalization
Micelles
nucleic acids
polymeric micelles
Polymers - chemistry
pulmonary delivery
Transfection
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Summary:The prevalence of lung diseases is increasing year by year and existing drug therapies only provide symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative therapeutic approach owing to their potential to reform a homeostatic balance by upregulating protective genes or downregulating damaging genes. However, their inherent properties, such as poor stability, ineffective cellular uptake, negative charge and so on, hinder their clinical utility. Such limitations can be overcome by exploiting the functional chemistry of polymeric micelles (PMs) for site-specific delivery, transfection efficiency and improved stability. With this objective, the present work describes the advancements made in designing nucleic acid-based PMs for treating lung diseases followed by approaches requiring consideration for clinical applications.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2022-0260