Role of nucleic acid-based polymeric micelles in treating lung diseases

• Published in: Nanomedicine (London, England) England), 2022-10, Vol.17 (25), p.1951-1960
• Main Authors: Kaur, Jaskiran, Gulati, Monica, Corrie, Leander, Awasthi, Ankit, Jha, Niraj Kumar, Chellappan, Dinesh Kumar, Gupta, Gaurav, MacLoughlin, Ronan, Oliver, Brian G, Dua, Kamal, Singh, Sachin Kumar
• Format: Article
• Language: English
• Subjects: Biological Transport; Drug Carriers - chemistry; Drug Delivery Systems; functionalization; Micelles; nucleic acids; polymeric micelles; Polymers - chemistry; pulmonary delivery; Transfection
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2022-0260

The prevalence of lung diseases is increasing year by year and existing drug therapies only provide symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative therapeutic approach owing to their potential to reform a homeostatic balance by upregulating protective genes or downregulating damaging genes. However, their inherent properties, such as poor stability, ineffective cellular uptake, negative charge and so on, hinder their clinical utility. Such limitations can be overcome by exploiting the functional chemistry of polymeric micelles (PMs) for site-specific delivery, transfection efficiency and improved stability. With this objective, the present work describes the advancements made in designing nucleic acid-based PMs for treating lung diseases followed by approaches requiring consideration for clinical applications.