Corticosteroid treatment attenuates anxiety and mPFC-amygdala circuit dysfunction in allergic asthma

Allergic asthma is associated with anxiety-related behaviors, leading to poor quality of life. Previous studies mainly described the neuropathophysiology of asthma-induced anxiety. However, the effects of corticosteroids, the most common anti-inflammatory agents for asthma treatment, on the neurophy...

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Published in:Life sciences (1973) 2023-02, Vol.315, p.121373-121373, Article 121373
Main Authors: Dehdar, Kolsoum, Mooziri, Morteza, Samii Moghaddam, Ali, Salimi, Morteza, Nazari, Milad, Dehghan, Samaneh, Jamaati, Hamidreza, Salimi, Alireza, Raoufy, Mohammad Reza
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adrenal Cortex Hormones - therapeutic use
Amygdala
Androstadienes - adverse effects
Animals
Anxiety
Anxiety - drug therapy
Asthma
Asthma - chemically induced
Corticosteroid
Fluticasone - therapeutic use
mPFC
Prefrontal Cortex
Quality of Life
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Summary:Allergic asthma is associated with anxiety-related behaviors, leading to poor quality of life. Previous studies mainly described the neuropathophysiology of asthma-induced anxiety. However, the effects of corticosteroids, the most common anti-inflammatory agents for asthma treatment, on the neurophysiological foundations of allergic asthma-induced anxiety are unexplored. Here, we evaluated lung and brain inflammation as well as anxiety in an animal model of allergic asthma pretreated with inhaled fluticasone propionate. Furthermore, to define the neurophysiological bases of these conditions, we studied the medial prefrontal cortex (mPFC)-amygdala circuit, which is previously shown to accompany asthma-induced anxiety. Our data showed that allergen induces anxiety, mPFC and amygdala inflammation, as well as disruptions in the local and long-range oscillatory activities within the mPFC-amygdala circuit. Interestingly, we observed a roughly consistent trend of changes with inhaled fluticasone pretreatment. Namely, the asthma-induced behavioral, inflammatory, and neurophysiological changes were partly, but not totally, prevented by inhaled fluticasone pretreatment. We suggest that early treatment of asthmatic patients with inhaled corticosteroids improves mPFC-amygdala circuit function by attenuating neuroinflammation leading to reduced anxiety. These findings could lead clinical guidelines of asthma to consider the neuropsychiatric disorders of patients in treatment recommendations.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2023.121373