Hypothesis: Viral infections of pregnant women may be early triggers of childhood type 1 diabetes and other autoimmune disease

Children and adolescents with early onset autoimmune diseases have a different seasonality of month of birth than the general population. This pattern is consistent with an infection during pregnancy affecting the fetus or an infection immediately after birth that act as early triggers of the autoim...

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Bibliographic Details
Published in:Journal of autoimmunity 2023-02, Vol.135, p.102977-102977, Article 102977
Main Authors: Laron, Zvi, Shulman, Lester, Hampe, Christiane, Blumenfeld, Orit
Format: Article
Language:English
Subjects:
Adolescent
Arthritis, Rheumatoid - complications
Atopic dermatitis
Autoimmune disease
Autoimmune Diseases
Child
Childhood
Diabetes Mellitus, Type 1
Female
Humans
Multiple sclerosis
Pregnancy
Pregnant Women
Thyroiditis
Type 1 diabetes
Virus Diseases - complications
Virus Diseases - epidemiology
Viruses
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Summary:Children and adolescents with early onset autoimmune diseases have a different seasonality of month of birth than the general population. This pattern is consistent with an infection during pregnancy affecting the fetus or an infection immediately after birth that act as early triggers of the autoimmune diseases. We present data supporting the use of Rotavirus vaccinations in the reduction of incidence of childhood T1D and propose further investigations into whether other anti-virus vaccinations may reduce the burden of other autoimmune diseases such as multiple sclerosis, atopic dermatitis, psoriasis and subtypes of rheumatoid arthritis, Hashimoto thyroiditis. •Viral infection in pregnant mothers may trigger an autoimmune disease in the fetus.•Children with autoimmune diseases have an abnormal seasonality of month of birth.•Specific vaccination of infants may reduce early childhood Type I diabetes.
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2022.102977