HLA-G in asthma and its potential as an effective therapeutic agent

Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of differ...

Full description

Saved in:
Bibliographic Details
Published in:Allergologia et immunopathologia 2023, Vol.51 (1), p.22-29
Main Authors: Li, Jinyan, Hao, Yuqiu, Li, Wei, Lv, Xuejiao, Gao, Peng
Format: Article
Language:English
Subjects:
Asthma
Autoimmune diseases
Chemokines
Dendritic cells
Disease
Immunoglobulins
Inflammation
Lymphocytes
Neutrophils
Pathogenesis
Phosphatase
Physiology
Preeclampsia
Tumor necrosis factor-TNF
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of different asthma phenotypes by regulating the activity and function of various immune cells. The mechanism of HLA-G in asthma is not fully clear, and there is no consensus on its mechanism in asthma. Further studies are needed to explore the role of HLA-G in different phenotypes of human asthma. Observational study. HLA-G is an important immunomodulatory factor in asthma. Studies have found different levels of HLA-G in patients with different asthma subtypes and healthy controls, but other studies have come to the opposite conclusion. We speculate that further study on the mechanism of HLA-G in asthma pheno-types may explain some of the contradictions in current studies. Findings should provide information regarding the potential of HLA-G as a novel target for asthma diagnosis and treatment.
ISSN:0301-0546
1578-1267
0301-0546
DOI:10.15586/aei.v51i1.650