Immunopathological insights into villitis of unknown etiology on the basis of transplant immunology

Villitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 +T cells into the placental villi. Although the pathogenesis of VUE is still debated, dysregulation of the immune system appears to be an important factor in the development of the disease...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2023-01, Vol.131, p.49-57
Main Authors: Damas, Ingrid Iara, Lavareze, Luccas, Scarini, João Figueira, de Lima-Souza, Reydson Alcides, Emerick, Carolina, Gonçalves, Mayara Trevizol, Figueiredo-Maciel, Tayná, Vieira, Gustavo de Souza, Kimura, Talita de Carvalho, Aquino, Iara Gonçalves, Paiva, João Paulo Gonçalves de, Helms, My N., Mariano, Fernanda Viviane, Altemani, Albina, Egal, Erika Said Abu
Format: Article
Language:English
Subjects:
Allographic rejection
Chorioamnionitis - pathology
Chorionic Villi - pathology
Female
Graft vs host disease
Graft vs Host Disease - complications
Graft vs Host Disease - pathology
Humans
Immunology
Placenta - pathology
Placenta Diseases - pathology
Pregnancy
Review
Villitis of unknown etiology
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Summary:Villitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 +T cells into the placental villi. Although the pathogenesis of VUE is still debated, dysregulation of the immune system appears to be an important factor in the development of the disease. Interaction of maternal T cells with the fetal antigens seems to be the trigger for the VUE onset. In this context, graft vs host disease (GVHD) and allographic rejection seem to share similarities in the VUE immunopathological mechanism, especially those related to immunoregulation. In this review, we compared the immunological characteristics of VUE with allograft rejection, and GVHD favoring a better knowledge of VUE pathogenesis that may contribute to VUE therapeutics strategies in the future. •VUE may be T cell-mediated in a non-selfie response as GVHD and allograft rejection.•Immune checkpoint inhibitors may imuneregulate VUE, GVHD, and allograft rejection.•Immunomodulation may be a therapeutic option to manage VUE in the near future.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2022.11.003