A novel prognostic system combining carbonic anhydrase II and preoperative CA19‐9 for intrahepatic cholangiocarcinoma after curative resection

Background The role of carbonic anhydrase II (CAII) in intrahepatic cholangiocarcinoma (ICC) was investigated and a novel prognostic system combining CAII and preoperative carbohydrate antigen 19‐9 (CA19‐9) was established to predict the survival of patients with ICC after curative resection. Method...

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Bibliographic Details
Published in:Cancer 2023-04, Vol.129 (7), p.1030-1040
Main Authors: Zhang, Jiawei, Huang, Qiming, Yang, Yi, Zhang, Jiahui, Fang, Xueting, Yang, Yubin, Liang, Huifang, Wang, Wei, Wang, Yanjun
Format: Article
Language:English
Subjects:
Antigens
Bile Duct Neoplasms
Bile Ducts, Intrahepatic - pathology
CA-19-9 Antigen
Calibration
carbohydrate antigen 19‐9
Carbohydrates
Carbonic anhydrase
Carbonic Anhydrase II
Cholangiocarcinoma
Cholangiocarcinoma - pathology
Continuity (mathematics)
Decisions
Humans
Immunohistochemistry
intrahepatic cholangiocarcinoma
Lymph nodes
Medical prognosis
Metastases
nomogram
Nomograms
Oncology
Patients
Prognosis
Retrospective Studies
Risk factors
Survival
Survival analysis
Tissue analysis
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Summary:Background The role of carbonic anhydrase II (CAII) in intrahepatic cholangiocarcinoma (ICC) was investigated and a novel prognostic system combining CAII and preoperative carbohydrate antigen 19‐9 (CA19‐9) was established to predict the survival of patients with ICC after curative resection. Methods A total of 110 patients who underwent curative‐intent resection for ICC between 2012 and 2020 were retrospectively analyzed. CAII in tumor and peritumor regions was examined by immunohistochemistry, and the relationships between clinicopathological factors and the prognostic value of CAII and CA19‐9 were analyzed. Results CAII was frequently downregulated in ICC tissues (p 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.34639