Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents

In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spar...

Full description

Saved in:
Bibliographic Details
Published in:Journal of enzyme inhibition and medicinal chemistry 2023-12, Vol.38 (1), p.2163241-2163241
Main Authors: Yang, Yu-Shun, Wang, Bin, Liu, Junzhong, Li, Qin, Jiao, Qin-Cai, Qin, Pei
Format: Article
Language:English
Subjects:
Allopurinol
Allopurinol - pharmacology
Allopurinol - therapeutic use
Animal models
Animals
Antioxidants
Biotechnology
Chromatography
Coastal marine sources
Coumaric acid
Coumaric Acids
Cytotoxicity
Humans
Hyperuricemia - drug therapy
Libraries
Life sciences
lowering uric acid
Mice
Nonnative species
Pharmaceuticals
Pharmacokinetics
Public health
Research Paper
Software
Spartina alterniflora
Uric acid
Uric Acid - therapeutic use
Xanthine oxidase
Xanthine Oxidase - metabolism
xanthine oxidase inhibition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3
cites cdi_FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3
container_end_page 2163241
container_issue 1
container_start_page 2163241
container_title Journal of enzyme inhibition and medicinal chemistry
container_volume 38
creator Yang, Yu-Shun
Wang, Bin
Liu, Junzhong
Li, Qin
Jiao, Qin-Cai
Qin, Pei
description In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spartinin C10 & C22 suggested high inhibition percentages (78.54 and 93.74) at 10 μM dosage, which were higher than the positive control Allopurinol. They were low cytotoxic onto human normal hepatocyte cells. Treatment with Spartinin C10 could lower the serum uric acid level to 440.0 μM in the hyperuricemic model mice (723.0 μM), comparable with Allopurinol (325.8 μM). Spartinin C10 was more appreciated than Allopurinol on other serum indexes. The preliminary pharmacokinetics evaluation indicated that the rapid absorption, metabolism and elimination of Spartinin C10 should be further improved. The discovery of pharmaceutical molecules from coastal marine source here might inspire the inter-disciplinary investigations on public health.
doi_str_mv 10.1080/14756366.2022.2163241
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_proquest_miscellaneous_2764441714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_f02744803eb04f5983842069dbcb86b4</doaj_id><sourcerecordid>2917549110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3</originalsourceid><addsrcrecordid>eNp9UstuEzEUtRCItoFPAFliwybBr_Fjg0ClQKVKbGBt-Zk6TMbFnkmVv8dD0oiyYGXr3nPPuY8DwCuMVhhJ9A4z0XHK-YogQlYEc0oYfgLO5_iSU8Genv6cn4GLWjcIEUwwew7OWogoxug56D-l6vIulD3MEbo8bU1JDhqXPPShpJ0Z0y5UeJuGMXho9w1j6mh6OAOHAGueigtwzLCG8BPGXOB0YujzfeMY1tCswzDWF-BZNH0NL4_vAvz4fPX98uvy5tuX68uPN0vXcTIuhVEGERRx18ZgHXE0Co6YspwHb120ygsnVeddJ7nC0VvhTfCRKiklEpYuwPWB12ez0XcltV73Opuk_wRyWWtTxuT6oCMiTUMiGixisVOSSkYQV03HSm5Z43p_4Lqb7DZ41-Yopn9E-jgzpFu9zjutJJOknWgB3h4JSv41hTrqbVt56HszhDxVTQRnjGGBZ603_0A3bbtDW5UmCouOKYxRQ3UHlCu51hLiqRmM9OwN_eANPXtDH73R6l7_Pcmp6sEMDfDhAEhDO-PW3OfSez2afZ9LLGZwqWr6f43f79TJXg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2917549110</pqid></control><display><type>article</type><title>Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents</title><source>Taylor &amp; Francis Open Access</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Yang, Yu-Shun ; Wang, Bin ; Liu, Junzhong ; Li, Qin ; Jiao, Qin-Cai ; Qin, Pei</creator><creatorcontrib>Yang, Yu-Shun ; Wang, Bin ; Liu, Junzhong ; Li, Qin ; Jiao, Qin-Cai ; Qin, Pei</creatorcontrib><description>In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spartinin C10 &amp; C22 suggested high inhibition percentages (78.54 and 93.74) at 10 μM dosage, which were higher than the positive control Allopurinol. They were low cytotoxic onto human normal hepatocyte cells. Treatment with Spartinin C10 could lower the serum uric acid level to 440.0 μM in the hyperuricemic model mice (723.0 μM), comparable with Allopurinol (325.8 μM). Spartinin C10 was more appreciated than Allopurinol on other serum indexes. The preliminary pharmacokinetics evaluation indicated that the rapid absorption, metabolism and elimination of Spartinin C10 should be further improved. The discovery of pharmaceutical molecules from coastal marine source here might inspire the inter-disciplinary investigations on public health.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.1080/14756366.2022.2163241</identifier><identifier>PMID: 36629443</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Allopurinol ; Allopurinol - pharmacology ; Allopurinol - therapeutic use ; Animal models ; Animals ; Antioxidants ; Biotechnology ; Chromatography ; Coastal marine sources ; Coumaric acid ; Coumaric Acids ; Cytotoxicity ; Humans ; Hyperuricemia - drug therapy ; Libraries ; Life sciences ; lowering uric acid ; Mice ; Nonnative species ; Pharmaceuticals ; Pharmacokinetics ; Public health ; Research Paper ; Software ; Spartina alterniflora ; Uric acid ; Uric Acid - therapeutic use ; Xanthine oxidase ; Xanthine Oxidase - metabolism ; xanthine oxidase inhibition</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2163241-2163241</ispartof><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. 2023</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. 2023 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3</citedby><cites>FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3</cites><orcidid>0000-0001-5424-8202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848256/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917549110?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27502,27924,27925,37012,37013,44590,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36629443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yu-Shun</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Liu, Junzhong</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Jiao, Qin-Cai</creatorcontrib><creatorcontrib>Qin, Pei</creatorcontrib><title>Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spartinin C10 &amp; C22 suggested high inhibition percentages (78.54 and 93.74) at 10 μM dosage, which were higher than the positive control Allopurinol. They were low cytotoxic onto human normal hepatocyte cells. Treatment with Spartinin C10 could lower the serum uric acid level to 440.0 μM in the hyperuricemic model mice (723.0 μM), comparable with Allopurinol (325.8 μM). Spartinin C10 was more appreciated than Allopurinol on other serum indexes. The preliminary pharmacokinetics evaluation indicated that the rapid absorption, metabolism and elimination of Spartinin C10 should be further improved. The discovery of pharmaceutical molecules from coastal marine source here might inspire the inter-disciplinary investigations on public health.</description><subject>Allopurinol</subject><subject>Allopurinol - pharmacology</subject><subject>Allopurinol - therapeutic use</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biotechnology</subject><subject>Chromatography</subject><subject>Coastal marine sources</subject><subject>Coumaric acid</subject><subject>Coumaric Acids</subject><subject>Cytotoxicity</subject><subject>Humans</subject><subject>Hyperuricemia - drug therapy</subject><subject>Libraries</subject><subject>Life sciences</subject><subject>lowering uric acid</subject><subject>Mice</subject><subject>Nonnative species</subject><subject>Pharmaceuticals</subject><subject>Pharmacokinetics</subject><subject>Public health</subject><subject>Research Paper</subject><subject>Software</subject><subject>Spartina alterniflora</subject><subject>Uric acid</subject><subject>Uric Acid - therapeutic use</subject><subject>Xanthine oxidase</subject><subject>Xanthine Oxidase - metabolism</subject><subject>xanthine oxidase inhibition</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9UstuEzEUtRCItoFPAFliwybBr_Fjg0ClQKVKbGBt-Zk6TMbFnkmVv8dD0oiyYGXr3nPPuY8DwCuMVhhJ9A4z0XHK-YogQlYEc0oYfgLO5_iSU8Genv6cn4GLWjcIEUwwew7OWogoxug56D-l6vIulD3MEbo8bU1JDhqXPPShpJ0Z0y5UeJuGMXho9w1j6mh6OAOHAGueigtwzLCG8BPGXOB0YujzfeMY1tCswzDWF-BZNH0NL4_vAvz4fPX98uvy5tuX68uPN0vXcTIuhVEGERRx18ZgHXE0Co6YspwHb120ygsnVeddJ7nC0VvhTfCRKiklEpYuwPWB12ez0XcltV73Opuk_wRyWWtTxuT6oCMiTUMiGixisVOSSkYQV03HSm5Z43p_4Lqb7DZ41-Yopn9E-jgzpFu9zjutJJOknWgB3h4JSv41hTrqbVt56HszhDxVTQRnjGGBZ603_0A3bbtDW5UmCouOKYxRQ3UHlCu51hLiqRmM9OwN_eANPXtDH73R6l7_Pcmp6sEMDfDhAEhDO-PW3OfSez2afZ9LLGZwqWr6f43f79TJXg</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Yang, Yu-Shun</creator><creator>Wang, Bin</creator><creator>Liu, Junzhong</creator><creator>Li, Qin</creator><creator>Jiao, Qin-Cai</creator><creator>Qin, Pei</creator><general>Taylor &amp; Francis</general><general>Taylor &amp; Francis Ltd</general><general>Taylor &amp; Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5424-8202</orcidid></search><sort><creationdate>202312</creationdate><title>Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents</title><author>Yang, Yu-Shun ; Wang, Bin ; Liu, Junzhong ; Li, Qin ; Jiao, Qin-Cai ; Qin, Pei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allopurinol</topic><topic>Allopurinol - pharmacology</topic><topic>Allopurinol - therapeutic use</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biotechnology</topic><topic>Chromatography</topic><topic>Coastal marine sources</topic><topic>Coumaric acid</topic><topic>Coumaric Acids</topic><topic>Cytotoxicity</topic><topic>Humans</topic><topic>Hyperuricemia - drug therapy</topic><topic>Libraries</topic><topic>Life sciences</topic><topic>lowering uric acid</topic><topic>Mice</topic><topic>Nonnative species</topic><topic>Pharmaceuticals</topic><topic>Pharmacokinetics</topic><topic>Public health</topic><topic>Research Paper</topic><topic>Software</topic><topic>Spartina alterniflora</topic><topic>Uric acid</topic><topic>Uric Acid - therapeutic use</topic><topic>Xanthine oxidase</topic><topic>Xanthine Oxidase - metabolism</topic><topic>xanthine oxidase inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yu-Shun</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Liu, Junzhong</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Jiao, Qin-Cai</creatorcontrib><creatorcontrib>Qin, Pei</creatorcontrib><collection>Taylor &amp; Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yu-Shun</au><au>Wang, Bin</au><au>Liu, Junzhong</au><au>Li, Qin</au><au>Jiao, Qin-Cai</au><au>Qin, Pei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2023-12</date><risdate>2023</risdate><volume>38</volume><issue>1</issue><spage>2163241</spage><epage>2163241</epage><pages>2163241-2163241</pages><issn>1475-6366</issn><eissn>1475-6374</eissn><abstract>In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spartinin C10 &amp; C22 suggested high inhibition percentages (78.54 and 93.74) at 10 μM dosage, which were higher than the positive control Allopurinol. They were low cytotoxic onto human normal hepatocyte cells. Treatment with Spartinin C10 could lower the serum uric acid level to 440.0 μM in the hyperuricemic model mice (723.0 μM), comparable with Allopurinol (325.8 μM). Spartinin C10 was more appreciated than Allopurinol on other serum indexes. The preliminary pharmacokinetics evaluation indicated that the rapid absorption, metabolism and elimination of Spartinin C10 should be further improved. The discovery of pharmaceutical molecules from coastal marine source here might inspire the inter-disciplinary investigations on public health.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>36629443</pmid><doi>10.1080/14756366.2022.2163241</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5424-8202</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1475-6366
ispartof Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2163241-2163241
issn 1475-6366
1475-6374
language eng
recordid cdi_proquest_miscellaneous_2764441714
source Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central
subjects Allopurinol
Allopurinol - pharmacology
Allopurinol - therapeutic use
Animal models
Animals
Antioxidants
Biotechnology
Chromatography
Coastal marine sources
Coumaric acid
Coumaric Acids
Cytotoxicity
Humans
Hyperuricemia - drug therapy
Libraries
Life sciences
lowering uric acid
Mice
Nonnative species
Pharmaceuticals
Pharmacokinetics
Public health
Research Paper
Software
Spartina alterniflora
Uric acid
Uric Acid - therapeutic use
Xanthine oxidase
Xanthine Oxidase - metabolism
xanthine oxidase inhibition
title Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A53%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20coumaric%20acid%20derivatives%20hinted%20by%20coastal%20marine%20source%20to%20seek%20for%20uric%20acid%20lowering%20agents&rft.jtitle=Journal%20of%20enzyme%20inhibition%20and%20medicinal%20chemistry&rft.au=Yang,%20Yu-Shun&rft.date=2023-12&rft.volume=38&rft.issue=1&rft.spage=2163241&rft.epage=2163241&rft.pages=2163241-2163241&rft.issn=1475-6366&rft.eissn=1475-6374&rft_id=info:doi/10.1080/14756366.2022.2163241&rft_dat=%3Cproquest_doaj_%3E2917549110%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c562t-7a9a020f15374452c3f76049b66edbcfb9d7c895dc58691fdb7daedf3988807b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2917549110&rft_id=info:pmid/36629443&rfr_iscdi=true