Inflammatory and Nutritional Status Influences Outcomes of Minimally Invasive Esophagectomy

Introduction The potential association between severe postoperative complications (SPC) and the oncological outcomes of esophageal squamous cell carcinoma (ESCC) patients according to the different Naples Prognostic Score (NPS) of the inflammatory nutritional status after minimally invasive esophage...

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Bibliographic Details
Published in:World journal of surgery 2023-04, Vol.47 (4), p.1003-1017
Main Authors: Xu, Shao-jun, Wang, Ping-lan, Chen, Chao, You, Cheng-xiong, Chen, Rui-qin, Wu, Wen-wei, Chen, Shu-chen
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cardiac Surgery
Complications
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Squamous Cell Carcinoma - surgery
Esophagectomy - adverse effects
General Surgery
Humans
Inflammation
Inflammatory response
Invasiveness
Malnutrition
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Nomograms
Nutritional Status
Original Scientific Report
Postoperative
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Prognosis
Retrospective Studies
Squamous cell carcinoma
Surgery
Survival
Survival analysis
Thoracic Surgery
Vascular Surgery
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Summary:Introduction The potential association between severe postoperative complications (SPC) and the oncological outcomes of esophageal squamous cell carcinoma (ESCC) patients according to the different Naples Prognostic Score (NPS) of the inflammatory nutritional status after minimally invasive esophagectomy (MIE) is unclear. Methods Kaplan–Meier survival analysis was used to evaluate overall survival (OS) and disease-free survival (DFS) between with or without SPC (Clavien–Dindo grade ≥ III) in low NPS status (NPS = 0 or 1) and high NPS status (NPS = 2 or 3 or 4) patients. Cox multivariable analysis was carried out to analyze the various independent factors of OS and DFS, and a nomogram based on SPC was established. Results A total of 20.7% (125/604) ESCC patients developed SPC after MIE. Patients with SPC exhibited poor 5-year OS and DFS compared to those without SPC (all P  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-023-06890-0