Effects of anterior thalamic nucleus DBS on interictal heart rate variability in patients with refractory epilepsy

•We examined the effect of anterior thalamic nucleus (ANT)-deep brain stimulation (DBS) on heart rate variability (HRV) in patients with drug-resistant epilepsy.•ANT-DBS increased HRV in patients irrespective of responder-status, ANT-hit ratio-seemed to influence HRV-changes.•ANT-DBS might positivel...

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Published in:Clinical neurophysiology 2023-03, Vol.147, p.17-30
Main Authors: Lőrincz, Katalin, Bóné, Beáta, Karádi, Kázmér, Kis-Jakab, Greta, Tóth, Natália, Halász, László, Erőss, Loránd, Balás, István, Faludi, Béla, Jordán, Zsófia, Chadaide, Zoltan, Gyimesi, Csilla, Fabó, Dániel, Janszky, József
Format: Article
Language:English
Subjects:
Anterior Thalamic Nuclei
Arrhythmias, Cardiac
Deep brain stimulation
Deep Brain Stimulation - methods
Drug Resistant Epilepsy
Drug-resistant
Epilepsy
Epilepsy - therapy
Heart Rate - physiology
Heart rate variability
Humans
Retrospective Studies
Thalamus
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Summary:•We examined the effect of anterior thalamic nucleus (ANT)-deep brain stimulation (DBS) on heart rate variability (HRV) in patients with drug-resistant epilepsy.•ANT-DBS increased HRV in patients irrespective of responder-status, ANT-hit ratio-seemed to influence HRV-changes.•ANT-DBS might positively influence autonomic regulation, additional prospective studies are required to replicate this finding. Heart rate variability (HRV) changes were investigated by several studies after resective epilepsy surgery/vagus nerve stimulation. We examined anterior thalamic nucleus (ANT)-deep brain stimulation (DBS) effects on HRV parameters. We retrospectively analyzed 30 drug-resistant epilepsy patients’ medical record data and collected electrocardiographic epochs recorded during video- electroencephalography monitoring sessions while awake and during N1- or N2-stage sleep pre-DBS implantation surgery, post-surgery but pre-stimulation, and after stimulation began. The mean square root of the mean squared differences between successive RR intervals and RR interval standard deviation values differed significantly (p 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2022.11.020