Association of lipoprotein(a) with left ventricular hypertrophy in patients with new-onset acute myocardial infarction: A large cross-sectional study

• Published in: Clinica chimica acta 2023-02, Vol.540, p.117226-117226, Article 117226
• Main Authors: Wang, Zhen-Wei, Xiao, Sheng-Jue, Liu, Nai-Feng
• Format: Article
• Language: English
• Subjects: Acute myocardial infarction; Cross-Sectional Studies; Female; Humans; Hypertension; Hypertrophy, Left Ventricular - complications; Left ventricular hypertrophy; Lipoprotein(a); Male; Middle Aged; Myocardial Infarction - complications; Renal Insufficiency, Chronic; Risk Factors
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2023.117226

•Lp(a) was closely associated with LVH.•Association between Lp(a) and LVH persisted in most subgroups.•Lp(a) remained significantly associated with LVH in sensitivity analyses. The association of lipoprotein(a) [Lp(a)] with echocardiography-estimated left ventricular hypertrophy (LVH) in high-risk population remains uncertain, so we assessed the association between Lp(a) with echocardiography-derived LVH in patients with new-onset acute myocardial infarction (AMI). In this large, single-center, cross-sectional observational study, we enrolled 2,096 patients with new-onset AMI. Lp(a) was used as the independent variable and LVH was used as the dependent variable. Logistic regression, subgroup and sensitivity analysis were performed to test the association of Lp(a) with LVH. The concentration of Lp(a) was higher in LVH group compared with the non-LVH group (P