Investigating family history of diabetes as a predictor of fasting insulin and fasting glucose activity in a sample of healthy weight adults

Aims Type 2 diabetes is a major public health problem for the global community. Having a family history of diabetes significantly increases risk for diabetes development and understanding how family history contributes to diabetes risk could lead to more effective prevention efforts for at-risk indi...

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Bibliographic Details
Published in:Acta diabetologica 2023-04, Vol.60 (4), p.535-543
Main Authors: Denton, Jessica J., Cedillo, Yenni E.
Format: Article
Language:English
Subjects:
Adult
Blood Glucose
Child
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Ethnicity
Fasting
Gender
Glucose
Health care
Humans
Insulin
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Minority & ethnic groups
Nutrition Surveys
Original Article
Public health
Regression analysis
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Summary:Aims Type 2 diabetes is a major public health problem for the global community. Having a family history of diabetes significantly increases risk for diabetes development and understanding how family history contributes to diabetes risk could lead to more effective prevention efforts for at-risk individuals. In a previous study, we showed family history of diabetes is a significant predictor of fasting insulin in healthy weight children. The present study aimed to use the National Health and Nutrition Examination Survey (NHANES 2017) to apply similar multiple regression models to a population of healthy weight adults to determine if family history is a significant predictor of fasting glucose and fasting insulin. Methods Fasting glucose (mg/dL) and fasting insulin (pmol/L) were used as dependent variables in each model, respectively, with family history of diabetes as the independent variable. Covariates for each model included age, gender, race/ethnicity, waist circumference, and macronutrient intake. Results The model significantly predicted the variance of fasting glucose [(F(11,364) = 34.80, p  
ISSN:1432-5233
0940-5429
1432-5233
DOI:10.1007/s00592-023-02030-1