Alactic base excess is an independent predictor of death in sepsis: A propensity score analysis

Alactic base excess (ABE) is a novel biomarker defined as the sum of lactate and standard base excess and estimates the renal capability of handling acid-base disturbances in sepsis. The objective of this study is to see if ABE is an independent predictor of mortality in septic patients with and wit...

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Bibliographic Details
Published in:Journal of critical care 2023-04, Vol.74, p.154248-154248, Article 154248
Main Authors: Cantos, Joaquín, Huespe, Iván A., Sinner, Jorge F., Prado, Eduardo M., Roman, Eduardo San, Rolón, Nicolás Contrera, Musso, Carlos G.
Format: Article
Language:English
Subjects:
Acidosis
Acute kidney injury
Alactic base excess
Biomarkers
Confounding (Statistics)
Creatinine
Critical care
Electronic health records
Hospitalization
Humans
Hyperlactatemia
Hypotheses
Kidney Diseases
Kidneys
Medical prognosis
Metabolism
Missing data
Mortality
Prognosis
Propensity Score
Retrospective Studies
Sepsis
Septic shock
Shock, Septic
Variables
Ventilators
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Summary:Alactic base excess (ABE) is a novel biomarker defined as the sum of lactate and standard base excess and estimates the renal capability of handling acid-base disturbances in sepsis. The objective of this study is to see if ABE is an independent predictor of mortality in septic patients with and without renal dysfunction. We retrospectively studied 1178 patients with sepsis and septic shock. Patients were divided according to ABE values: 1) negative ABE ( 60 mL/min/1.73 m2 (n = 493), we observed higher mortality in patients with negative ABE (adjusted HR 2.43; 95%CI 1.07–5.53). Negative ABE is an independent predictor of in-hospital mortality in septic patients with and without renal dysfunction.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2022.154248