Programmed Death of Microglia in Alzheimer’s Disease: Autophagy, Ferroptosis, and Pyroptosis

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Increasing evidence has demonstrated that the damage of cell plays an important rol...

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Bibliographic Details
Published in:The journal of prevention of Alzheimer's disease 2023, Vol.10 (1), p.95-103
Main Authors: Qiu, Z., Zhang, H., Xia, M., Gu, J., Guo, K., Wang, H., Miao, Changhong
Format: Article
Language:English
Subjects:
Alzheimer Disease
Autophagy
Ferroptosis
Geriatrics/Gerontology
Humans
Medicine
Medicine & Public Health
Microglia - metabolism
Microglia - pathology
Neurology
Pyroptosis
Review
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Summary:Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Increasing evidence has demonstrated that the damage of cell plays an important role in AD. Cell death is a critical phenomenon for physiological functions, which promotes AD pathogenesis. Programmed cell death, including necroptosis, pyroptosis, autophagy, and ferroptosis, have been discovered that have unique biological functions and pathophysiological characteristics. Here, we review the available evidence detailing the mechanisms of programmed microglial death, including pyroptosis, autophagy, and ferroptosis. We also highlight the role of programmed death of microglia during the process of AD and focus on the connection between the disease and cell death.
ISSN:2426-0266
DOI:10.14283/jpad.2023.3