Prevalence and incidence of HEV among men using HIV pre-exposure prophylaxis: A sub-study of the ANRS IPERGAY trial

Men who have sex with men (MSM) have an increased risk of infection by pathogens transmitted by the oro-fecal route. Here, we investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in 416 MSM included in the ANRS IPERGAY PrEP trial. Among the 62 (14.9% (95% CI: [11.6%-18....

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical virology 2023-03, Vol.160, p.105380-105380, Article 105380
Main Authors: Chaix, Marie-Laure, Leturque, Nicolas, Gabassi, Audrey, Charreau, Isabelle, Minier, Marine, Pialoux, Gilles, Cua, Éric, Chidiac, Christian, Raffi, François, Tremblay, Cécile, Meyer, Laurence, Molina, Jean-Michel, Delaugerre, Constance
Format: Article
Language:English
Subjects:
Hepatitis E - epidemiology
Hepatitis E virus
HIV Infections
HIV pre-exposure prophylaxis
Homosexuality, Male
Humans
Incidence
Male
MSM
Pre-Exposure Prophylaxis
Prevalence
Seroepidemiologic Studies
Seroprevalence
Sexual and Gender Minorities
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Men who have sex with men (MSM) have an increased risk of infection by pathogens transmitted by the oro-fecal route. Here, we investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in 416 MSM included in the ANRS IPERGAY PrEP trial. Among the 62 (14.9% (95% CI: [11.6%-18.7%]) seropositive for HEV at inclusion, the only factor associated with testing seropositive for HEV was older age. Geographical origin, use of recreational drugs, number of sexual partners, status for HAV and bacterial sexually transmitted infection (STI) at inclusion were not associated. Among the 342 HEV-seronegative patients with available samples, 9 seroconverted after a median of follow-up of 2.1 years (IQR (interquartile range): [1.6; 3.0]). Overall, the HEV incidence was 1.19% per 100 person-years [95% CI: 0.54%; 2.26%]. Sexual transmission does not seem to be a major route of HEV infection in MSM, unlike HAV.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2023.105380