Nanoparticle-based chewable gels of praziquantel

Chewable gels present significant advantages over conventional dosage forms, despite their development is not comprehensively assessed. In this sense, six formulations, varying gelatine concentration, dose, and form of incorporation of praziquantel, were developed and characterized. The novelty of t...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2023-01, Vol.28 (1), p.143-151
Main Authors: Gonzalez, M. Alejandra, Ramírez-Rigo, M. Verónica, Gonzalez Vidal, Noelia L.
Format: Article
Language:English
Subjects:
Administration, Oral
Antihelmintic
chewable gels
Food
gelatine
Gels
Nanoparticles
Praziquantel
Solubility
Water
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Summary:Chewable gels present significant advantages over conventional dosage forms, despite their development is not comprehensively assessed. In this sense, six formulations, varying gelatine concentration, dose, and form of incorporation of praziquantel, were developed and characterized. The novelty of this approach focused not only on the development of the formulation itself but also on the incorporation of the drug in a nanoparticulated form. The obtained results for moisture content, water activity, pH, and drug content were within the expected values for this type of formulation. On the other hand, texture and disintegration parameters were influenced by the form of incorporation of praziquantel and the amount of gelatine added. Finally, in vitro dissolution of chewable gels showed significant differences with intermediate products, though the improved dissolution of the nanoparticulated drug was maintained. In conclusion, nanoparticulate drugs can be incorporated into these semisolid formulations and could be successfully applied to other low-aqueous solubility drugs.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450.2023.2169455