L‐Arginine‐Functionalized Carbon Dots with Enhanced Red Emission and Upregulated Intracellular L‐Arginine Intake for Obesity Inhibition

Obesity is a major global health problem that significantly increases the risk of many other diseases. Herein, a facile method of suppressing lipogenesis and obesity using L‐arginine‐functionalized carbon dots (L‐Arg@CDots) is reported. The prepared CDots with a negative surface charge form stronger...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-08, Vol.19 (31), p.e2206667-n/a
Main Authors: Wang, Liming, Li, Licen, Wang, Bingzhe, Wu, Jun, Liu, Yupeng, Liu, Enshan, Zhang, Huiqi, Zhang, Bohan, Xing, Guichuan, Li, Qinglin, Tang, Zikang, Deng, Chuxia, Qu, Songnan
Format: Article
Language:English
Subjects:
Adipose tissue
Animals
Aqueous solutions
Arginine
bioimaging
Body weight
Bonding strength
Carbon - chemistry
Carbon dots
Emission spectra
Food intake
Lysine
L‐arginine
Mice
Nanotechnology
Obesity
Photoluminescence
Public health
Quantum Dots - chemistry
Surface charge
surface modification
Water chemistry
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Summary:Obesity is a major global health problem that significantly increases the risk of many other diseases. Herein, a facile method of suppressing lipogenesis and obesity using L‐arginine‐functionalized carbon dots (L‐Arg@CDots) is reported. The prepared CDots with a negative surface charge form stronger bonds than D‐arginine and lysine with L‐Arg in water. The L‐Arg@CDots in the aqueous solution offer a high photoluminescence quantum yield of 23.6% in the red wavelength region. The proposed L‐Arg functionalization strategy not only protects the red emission of the CDots from quenching by water molecules but also enhances the intracellular uptake of L‐Arg to reduce lipogenesis. Injection of L‐Arg@CDots can reduce the body weight increase in ob/ob mice by suppressing their food intake and shrinking the white adipose tissue cells, thereby significantly inhibiting obesity. A facile method of suppressing lipogenesis and obesity using L‐arginine‐functionalized carbon dots (CDots) is reported. The difference in luminescence of L‐lysine, D‐arginine, and L‐arginine to explain the composite structure of CDots is compared with L‐arginine. This strategy not only protects the red emission of the CDots but also enhances the intracellular uptake of L‐Arg to inhibit obesity.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202206667