Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: a Kinetic Approach

The medical field now needs more novel drugs to treat obesity and type-2 diabetes mellitus (T2D) than ever before. Obesity and T2D are both characterized by resistance to the hormones leptin and insulin. PTP-1B is a promising target for drug growth, as strong genetic, pharmacological, and biochemica...

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Published in:Biological trace element research 2023-10, Vol.201 (10), p.5037-5052
Main Authors: Shaik, Ayub, Kondaparthy, Vani, Begum, Alia, Husain, Ameena, Manwal, Deva Das
Format: Article
Language:English
Subjects:
Analytical methods
Biochemistry
Biomedical and Life Sciences
Biotechnology
Coordination compounds
Diabetes
Diabetes mellitus
Emission spectroscopy
Enzyme kinetics
Enzymes
Fluorescence
Hormones
Inhibitors
Insulin
Kinetics
Leptin
Life Sciences
Metal complexes
Metals
Molecular modelling
Nutrition
Obesity
Oncology
Proteins
Spectroscopy
Vanadium
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Summary:The medical field now needs more novel drugs to treat obesity and type-2 diabetes mellitus (T2D) than ever before. Obesity and T2D are both characterized by resistance to the hormones leptin and insulin. PTP-1B is a promising target for drug growth, as strong genetic, pharmacological, and biochemical evidence points to the possibility of treating diabetes and obesity by blocking the PTP-1B enzyme. Studies have also found that PTP-1B is overexpressed in patients with diabetes and obesity, suggesting that inhibiting PTP-1B may be a useful technique in their care. There are no clinically used PTP-1B inhibitors, despite the fact that numerous naturally occurring PTP-1B inhibitors have demonstrated great therapeutic promise. This is most likely due to their low activity or lack of selectivity. It is still important to look for more effective and focused PTP-1B inhibitors. A few organovanadium metal complexes were synthesized and characterized, and binding studies on vanadium complexes with PTP-B were also performed using fluorescence emission spectroscopy. Additionally, we theoretically (molecular modeling) and experimentally (enzyme kinetics) examined the PTP-1B inhibitory effects of these vanadium metal complexes and found that they have excellent PTP-1B inhibitory properties.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-023-03557-8