An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering

Bone regeneration or restoration is a series of well-ordered physiological activities that occur throughout a person’s life, they are continuously being repaired and remodeled. A conventional bone repair procedure, such as autograft and allograft bone transplant, has failed to address bone reconstru...

Full description

Saved in:
Bibliographic Details
Published in:Applied biochemistry and biotechnology 2023-07, Vol.195 (7), p.4617-4636
Main Authors: Vijayalekha, Ashwathi, Anandasadagopan, Suresh Kumar, Pandurangan, Ashok Kumar
Format: Article
Language:English
Subjects:
Allografts
Autografts
Biochemistry
Biomaterials
Biomedical materials
Biotechnology
Bone biomaterials
Bone grafts
Bone growth
Bone healing
Bone matrix
Bones
Chemistry
Chemistry and Materials Science
Collagen
Collagen (type I)
Crosslinking
Extracellular matrix
Fabrication
Human tissues
Osteogenesis
Regeneration
Regeneration (physiology)
Review Article
Scaffolding
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bone regeneration or restoration is a series of well-ordered physiological activities that occur throughout a person’s life, they are continuously being repaired and remodeled. A conventional bone repair procedure, such as autograft and allograft bone transplant, has failed to address bone reconstruction disputes and complexity. On the other hand, Tissue Engineering is a potential therapy option for repairing rather than replacing the damaged tissue. Biomaterials in bone tissue engineering (BTE) help pave the way for damaged tissues as an artificial extracellular matrix, facilitating new tissue growth. Collagen-based biomaterials for repair and replacement have inspired much interest in the hunt for versatile biomaterials compatible with human tissue. It is a major organic component of extracellular matrix in bone and has been employed as scaffolding material in BTE for decades. In this review, we documented the role of collagen in BTE, focusing on collagen type I, its crosslinking capability, collagen-based biomaterials, and fabrication methods. It also considers osteoblast citration a critical process in bone formation, a unique perspective for an old relationship.
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-023-04318-y