The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Penile cancer is a rare malignancy, with a European-wide annual incidence rate of 1/100 000 males. Approximately one-third of cases are attributable to human papillomavirus (HPV) infection. p16 is a recognized surrogate marker for HPV infection in penile cancer. University Hospital Waterford (UHW) i...

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Bibliographic Details
Published in:Canadian Urological Association journal 2022-12, Vol.16 (12), p.435-438
Main Authors: Browne, Eva, Power Foley, Megan, O'Kelly, John, Ríogh, Aisling Nic An, Shah, Nigam, Shilling, Christine, Keane, John P, Daly, Padraig, Cullen, Ivor M
Format: Article
Language:English
Subjects:
Complications and side effects
Diagnosis
Papillomavirus infections
Penile cancer
Risk factors
Statistics
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Summary:Penile cancer is a rare malignancy, with a European-wide annual incidence rate of 1/100 000 males. Approximately one-third of cases are attributable to human papillomavirus (HPV) infection. p16 is a recognized surrogate marker for HPV infection in penile cancer. University Hospital Waterford (UHW) is the national referral center for penile cancer in Ireland. We report the prevalence of HPV infection and histological characteristics of an Irish penile cancer cohort using p16 as a surrogate marker. Patients who attended UHW for penile cancer surgery between June 2015 and November 2020 were entered into a prospectively maintained database. Clinical, histopathological, and outcome data were collected. Over the study period, 70 patients with a histological diagnosis of penile squamous cell carcinoma had staining for p16 , of whom 64% were positive. p16 -positive patients were significantly younger at diagnosis, with a mean age of 61±15 years compared to 68±12 (p
ISSN:1911-6470
1920-1214
DOI:10.5489/cuaj.7821