Fuligopyrones from the Fruiting Bodies of Myxomycete Fuligo septica Offer Short-Term Protection from Abiotic Stress Induced by UV Radiation

The myxomycete Fuligo septica, colloquially referred to as “dog vomit fungus”, forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal climatic conditions in Sydney, Australia, provided a rare opportunity to access abundant quantities...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2023-03, Vol.86 (3), p.633-637
Main Authors: Minns, Scott A., Bowles, Simon, Lacey, Ernest, Kalaitzis, John A., Vuong, Daniel, Butler, Mark S., Piggott, Andrew M.
Format: Article
Language:English
Subjects:
abiotic stress
absorption
Animals
Ascomycota
Australia
bioactive properties
Dogs
Fruiting Bodies, Fungal
fungi
isomers
Myxomycetes - chemistry
pyrones
spring
ultraviolet radiation
Ultraviolet Rays
wood
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Summary:The myxomycete Fuligo septica, colloquially referred to as “dog vomit fungus”, forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal climatic conditions in Sydney, Australia, provided a rare opportunity to access abundant quantities of F. septica aethalia, which enabled the isolation, purification, structure elucidation, and biological screening of two avenalumamide pyrones, fuligopyrone (1) and fuligopyrone B (2). While 1 and 2 did not exhibit any appreciable biological activity, their significant UV absorption at 325 nm suggested they may be acting as transient sunscreens to help protect the fruiting mass from exposure to sunlight. In support of this hypothesis, exposing a solution of 2 to direct sunlight for 5 min resulted in rapid equilibration with a mixture of 2E,4Z-fuligopyrone B (10) and 2Z,4E-fuligopyrone B (11) photoisomers.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.2c00989