The research progress of Wnt/β-catenin signaling pathway in colorectal cancer

The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membrane, cytoplasm, and nucleus, inhibiting or activating these pat...

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Bibliographic Details
Published in:Clinics and research in hepatology and gastroenterology 2023-03, Vol.47 (3), p.102086-102086, Article 102086
Main Authors: Zhang, Xueling, Li, Congcong, Wu, Yue, Cui, Peilin
Format: Article
Language:English
Subjects:
beta Catenin - metabolism
Cell Line, Tumor
Cell Proliferation - genetics
Colorectal cancer
Colorectal Neoplasms - pathology
Crosstalk
Gene Expression Regulation, Neoplastic
Humans
LncRNA
Signaling pathway
Tumor Microenvironment
Wnt
Wnt Signaling Pathway - physiology
β-catenin
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Summary:The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membrane, cytoplasm, and nucleus, inhibiting or activating these pathway proteins presents a novel target for cancer treatment via the Wnt signaling pathway. Studies have found that this pathway plays a significant role in the formation and progression of cancers, particularly colorectal cancer. We summarised the activation and inhibition of the Wnt signaling pathway in tumors, its relationship with the microenvironment and crosstalk with other pathways, and the effect of targeting abnormal Wnt signaling in the treatment of colorectal cancer. Here is to review future targeted therapeutics in colorectal cancer research and implementation.
ISSN:2210-7401
2210-741X
DOI:10.1016/j.clinre.2023.102086