The research progress of Wnt/β-catenin signaling pathway in colorectal cancer

• Published in: Clinics and research in hepatology and gastroenterology 2023-03, Vol.47 (3), p.102086-102086, Article 102086
• Main Authors: Zhang, Xueling, Li, Congcong, Wu, Yue, Cui, Peilin
• Format: Article
• Language: English
• Subjects: beta Catenin - metabolism; Cell Line, Tumor; Cell Proliferation - genetics; Colorectal cancer; Colorectal Neoplasms - pathology; Crosstalk; Gene Expression Regulation, Neoplastic; Humans; LncRNA; Signaling pathway; Tumor Microenvironment; Wnt; Wnt Signaling Pathway - physiology; β-catenin
• ISSN: 2210-7401; 2210-741X
• DOI: 10.1016/j.clinre.2023.102086

The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membrane, cytoplasm, and nucleus, inhibiting or activating these pathway proteins presents a novel target for cancer treatment via the Wnt signaling pathway. Studies have found that this pathway plays a significant role in the formation and progression of cancers, particularly colorectal cancer. We summarised the activation and inhibition of the Wnt signaling pathway in tumors, its relationship with the microenvironment and crosstalk with other pathways, and the effect of targeting abnormal Wnt signaling in the treatment of colorectal cancer. Here is to review future targeted therapeutics in colorectal cancer research and implementation.