Prognostic markers for oral cancer: An overview of the current status and directions for future research

In the last decades, the search for biomarkers for response to therapy and prognosis, with potential of providing information about the likely course and outcome of disease, has been intense in oral squamous cell carcinomas. Although several biomarkers, ranging from genetic and molecular alterations...

Full description

Saved in:
Bibliographic Details
Published in:Journal of oral pathology & medicine 2023-04, Vol.52 (4), p.288-293
Main Authors: Oliveira, Lilianny Querino Rocha, Almangush, Alhadi, Al‐Samadi, Ahmed, Salo, Tuula, Coletta, Ricardo D.
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - genetics
Head and Neck Neoplasms
Humans
Mouth Neoplasms - diagnosis
Mouth Neoplasms - genetics
Mouth Neoplasms - pathology
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Prognosis
Squamous Cell Carcinoma of Head and Neck
treatment
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the last decades, the search for biomarkers for response to therapy and prognosis, with potential of providing information about the likely course and outcome of disease, has been intense in oral squamous cell carcinomas. Although several biomarkers, ranging from genetic and molecular alterations to clinical and histopathological features, have been described, only a few of them are used in routine practice. The aim of this review is to outline the recent advances in oral squamous cell carcinomas biomarkers, exploring those related to clinical and histopathological features, cancer cells and components of the tumor microenvironment. Future directions, highlighting the main issues that limit the clinical application of many of the potential biomarkers, are discussed.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13406