In silico testing of the universality of epithelial tissue growth

The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using...

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Bibliographic Details
Published in:Physical review. E 2022-12, Vol.106 (6), p.L062402-L062402, Article L062402
Main Authors: Mazarei, Mahmood, Åström, Jan, Westerholm, Jan, Karttunen, Mikko
Format: Article
Language:English
Subjects:
Epithelium
Kinetics
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Summary:The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the cellsim3d kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ- and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.
ISSN:2470-0045
2470-0053
DOI:10.1103/PhysRevE.106.L062402