A case of naturally occurring anti-Dia antibody in a young man

The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus...

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Published in:Asian journal of transfusion science 2022, Vol.16 (2), p.276-279
Main Authors: Iberahim, Salfarina, Noor, Noor Haslina Mohd, Hassan, Mohd Nazri, Bahar, Rosnah, Yusoff, Shafini Mohdmed, Ramli, Marini, Abdul Rahman, Wan Suriana Wan, Zulkafli, Zefarina, Abdullah, Marne, Fong, Ho Sook, Mohamed Shihabudin, Tengku Muzafar Tengku, Edinur, Hisham Atan, Che Ghazali, Norul Hajar
Format: Report
Language:English
Online Access:Get full text
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Summary:The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.
ISSN:0973-6247
DOI:10.4103/ajts.ajts_136_21